Document Detail

Relationships between neuronal birthdates and cytoarchitecture in the rat inferior olivary complex.
MedLine Citation:
PMID:  1770173     Owner:  NLM     Status:  MEDLINE    
The correlation between birthdates of neurons and their ultimate location within the inferior olivary nucleus (ION) was investigated in the rat by the 5-bromodeoxyuridine (BrdU) method. We performed injections every 4 hours throughout the ION generation period, and were thus able to demonstrate that 1) neurons are distributed in the adult ION following characteristic gradients that define subdivisions identical to those established by hodological studies; and 2) ION neurons born at the same time tend to be arrayed in small clusters in the adult structure. Implications of these findings for the mechanisms of olivary neuron migration, selective aggregation, and elaboration of projectional topography are discussed. This study provides direct evidence that one of the factors governing the elaboration of the cytoarchitecture of a neuronal nucleus is the temporal sequence of generation of its neurons.
F Bourrat; C Sotelo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  313     ISSN:  0021-9967     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-02-27     Completed Date:  1992-02-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  509-21     Citation Subset:  IM    
Laboratoire de Neuromorphologie, INSERM U106, Hôpital de la Salpêtrière, Paris.
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MeSH Terms
Brain Mapping
Cell Division
Neurons / cytology*
Olivary Nucleus / cytology*
Rats, Inbred Strains
Time Factors
Reg. No./Substance:

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