| Relationships between neuronal birthdates and cytoarchitecture in the rat inferior olivary complex. | |
| | |
MedLine Citation:
|
PMID: 1770173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The correlation between birthdates of neurons and their ultimate location within the inferior olivary nucleus (ION) was investigated in the rat by the 5-bromodeoxyuridine (BrdU) method. We performed injections every 4 hours throughout the ION generation period, and were thus able to demonstrate that 1) neurons are distributed in the adult ION following characteristic gradients that define subdivisions identical to those established by hodological studies; and 2) ION neurons born at the same time tend to be arrayed in small clusters in the adult structure. Implications of these findings for the mechanisms of olivary neuron migration, selective aggregation, and elaboration of projectional topography are discussed. This study provides direct evidence that one of the factors governing the elaboration of the cytoarchitecture of a neuronal nucleus is the temporal sequence of generation of its neurons. |
| | |
Authors:
|
F Bourrat; C Sotelo |
Related Documents
:
|
21155903 - Response to sensory uncertainty in parkinson's disease: a marker of cerebellar dysfunct... 1856333 - Cell migration in the rat embryonic neocortex. 19780343 - Epileptiform eeg spikes and their functional significance. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of comparative neurology Volume: 313 ISSN: 0021-9967 ISO Abbreviation: J. Comp. Neurol. Publication Date: 1991 Nov |
Date Detail:
|
Created Date: 1992-02-27 Completed Date: 1992-02-27 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0406041 Medline TA: J Comp Neurol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 509-21 Citation Subset: IM |
Affiliation:
|
Laboratoire de Neuromorphologie, INSERM U106, Hôpital de la Salpêtrière, Paris. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain Mapping Bromodeoxyuridine Cell Division Immunohistochemistry Neurons / cytology* Olivary Nucleus / cytology* Rats Rats, Inbred Strains Time Factors |
| Chemical | |
Reg. No./Substance:
|
59-14-3/Bromodeoxyuridine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adrenal steroids regulate postnatal development of the rat dentate gyrus: II. Effects of glucocortic...
Next Document: Type I corticosteroid receptor-like immunoreactivity in the rat CNS: distribution and regulation by ...