| Relationships between mechanical properties and extracellular matrix constituents of the cervical stroma during pregnancy. | |
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MedLine Citation:
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PMID: 19796726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In normal pregnancy, the cervix maintains its shape during a period of substantial fetal and uterine growth. Hence, maintenance of biomechanical integrity is an important aspect of cervical function. It is known that cervical mechanical properties arise from extracellular matrix (ECM). The most important constituent of the cervical ECM is fibrillar collagen-it is collagen protein that the cervix derives its "strength" from. Other matrix molecules known to affect the collagen network include water, proteoglycans, hyaluronan, and elastin. The objective of this review is to discuss relationships between biochemical constituents and macroscopic mechanical properties. The individual constituents of the ECM will be discussed, especially in regard to collagen remodeling during pregnancy. In addition, the macroscopic mechanical properties of cervical tissue will be reviewed. An improved understanding of the biochemistry of cervical "strength" will shed light on how the cervix maintains its shape in normal pregnancy and shortens in preterm birth. |
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Authors:
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Michael House; David L Kaplan; Simona Socrate |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Seminars in perinatology Volume: 33 ISSN: 1558-075X ISO Abbreviation: Semin. Perinatol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-02 Completed Date: 2010-02-01 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 300-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Tufts Medical Center, Boston, MA 02111, USA. mhouse@tuftsmedicalcenter.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biomechanics
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physiology Cervix Uteri / chemistry, physiology* Collagen / chemistry, physiology* Extracellular Matrix / chemistry, physiology* Female Humans Pregnancy Stromal Cells / physiology |
| Grant Support | |
ID/Acronym/Agency:
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2K12HD000849-21/HD/NICHD NIH HHS; K12 HD000849-12/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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