| Relationships between the islets blood flow, nitric oxide, insulin, and cytosolic calcium in rat pancreatic islets: Effects of DPP-IV inhibitor vildagliptin. | |
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MedLine Citation:
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PMID: 22155545 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aim of the present study was to evaluate the relationships between the islet blood flow, nitric oxide, insulin, and cytosolic calcium in rat pancreatic islets, using dipeptidyl peptidase-IV (DPP-IV) inhibitor vildagliptin. For measuring pancreatic and islet blood a non-radioactive microsphere technique was used. Vehicle pre-treatment of glucose administered diabetic rats had decrease pancreatic and islet blood flow as compared with glucose administered normal rats. Blood glucose concentrations were not affected after vildagliptin administration in either diabetic or normal rats (10min after glucose administration). Vildagliptin had no effects on baseline pancreatic or islet blood flow in glucose administered normal rats. Administration of vildagliptin increased both pancreatic and islet blood flow as compared with vehicle treated diabetic rats. Furthermore, diabetic rats showed significant increase in NO and decrease in insulin secretions and vice versa in normal rats. Vildagliptin pre-treatment to both normal and diabetic rats had shown mild decrease in NO, but significantly increased insulin secretions. In addition, vildagliptin itself is able to mobilize intracellular Ca(2+) in pancreatic islet both in absence and presence of glucose. From the present study, we conclude following points (A) administration of vildagliptin augmented the blood flow seen in islets of diabetic rats, (B) islet insulin secretions are independent of islet blood flow and NO, (C) vildagliptin inhibited excessive NO production in diabetic rats that prevents the damage to β-cells due to excessive production of peroxynitrite (ONOO(-)) ions and protects from cytokine-induced suppression of insulin release. |
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Authors:
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Atul Sureshrao Akarte; B P Srinivasan; Sonia Gandhi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-3 |
Journal Detail:
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Title: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Volume: - ISSN: 1879-0720 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9317982 Medline TA: Eur J Pharm Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar, Sector-3, MB Road, New Delhi 110017, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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