| Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes. | |
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MedLine Citation:
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PMID: 10653827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It has been suggested by clinical, epidemiological, and experimental in vitro studies that homocysteine potentiates thrombin generation. This prothrombotic effect however has not previously been demonstrated in patients presenting with acute coronary syndromes (ACS). METHODS AND RESULTS: Patients with ACS (n =117) presenting with confirmed acute myocardial infarction (MI) (n =57) or unstable angina pectoris (UAP) (n =60) were consecutively recruited together with patients (n =18) in whom the presenting chest pain was not of cardiac origin (NCP), included as controls. Plasma samples were collected on admission and before clinical intervention. Homocysteine was assayed by high performance liquid chromatography, and both Factor VIIa and prothrombin fragment F1+2 were analyzed by ELISA. There were significant elevations in F1+2 in MI (P<0.001) and UAP (P=0.003), and modest elevations in Factor VIIa in UAP (P<0.05) compared with NCP but no differences in homocysteine levels among those groups. On dividing patients with ACS into quartiles of homocysteine, there was a stepwise increase in F1+2 (P<0.0001) and of Factor VIIa (P<0.05). There were significant correlations in ACS between homocysteine and F1+2 (r=0.46, P<0.0001), homocysteine and Factor VIIa (r=0.24, P<0.01), and F1+2 and Factor VIIa (r=0.41, P<0.0001). There was no correlation between homocysteine and either F1+2 (r=-0.15, P=0.57) or Factor VIIa (r=0. 22, P=0.37) in the NCP patients. CONCLUSIONS: Elevated plasma homocysteine is associated with and may cause elevated Factor VIIa and thrombin generation in patients presenting with ACS. These findings suggest an explanation for the prothrombotic effect of homocysteine in ACS. |
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Authors:
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M K Al-Obaidi; H Philippou; P J Stubbs; A Adami; R Amersey; M M Noble; D A Lane |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation Volume: 101 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-02-18 Completed Date: 2000-02-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 372-7 Citation Subset: AIM; IM |
Affiliation:
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National Heart and Lung Institute, Cardiology and Haematology Departments, Charing Cross Campus, Imperial College School of Medicine, London, UK. m.al-obaidi@rbh.nthames.nhs.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Angina, Unstable / blood* Biological Markers / blood Chest Pain Cholesterol / blood Cholesterol, HDL / blood Chromatography, High Pressure Liquid Diabetes Mellitus / blood Enzyme-Linked Immunosorbent Assay Factor VIIa / analysis, metabolism* Female Homocysteine / blood* Humans Hypertension / blood Male Middle Aged Myocardial Infarction / blood* Smoking Thrombin / analysis, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cholesterol, HDL; 454-28-4/Homocysteine; 57-88-5/Cholesterol; EC 3.4.21.21/Factor VIIa; EC 3.4.21.5/Thrombin |
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