Document Detail

Relationships between essential fatty acid levels, pulmonary function and fat absorption in pre-adolescent cystic fibrosis children with good clinical scores.
MedLine Citation:
PMID:  2707278     Owner:  NLM     Status:  MEDLINE    
Twenty-one pre-adolescent cystic fibrosis (CF) children with good clinical scores had significant (P less than 0.001) deficiencies of arachidonic (mean 3.8% of total plasma fatty acids +/- SD 1.4) and linoleic (18.1 +/- 6.3) acids compared with controls (6.0 +/- 1.0, and 27.6 +/- 3.9, respectively). Despite the presence of pulmonary involvement of varying severity in all the CF children, neither arachidonic nor linoleic acid levels correlated significantly with pulmonary function measured by spirometry. All children had adequate caloric and fat intakes, and the coefficient of fat absorption correlated with none of the deficient fatty acid levels. These findings suggest that deficiencies of arachidonic and linoleic acids are of minor importance in the early development of pulmonary involvement in CF, and that factors other than fat malabsorption and decreased dietary intake probably contribute to fatty acid deficiency.
G N Thompson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pediatrics     Volume:  148     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-06-08     Completed Date:  1989-06-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  327-9     Citation Subset:  IM    
Department of Chemical Pathology, Adelaide Children's Hospital, South Australia.
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MeSH Terms
Child, Preschool
Cystic Fibrosis / blood*
Dietary Fats / metabolism*
Fatty Acids, Essential / blood,  deficiency*
Intestinal Absorption*
Lung Volume Measurements*
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids, Essential

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