| Relationships between essential fatty acid levels, pulmonary function and fat absorption in pre-adolescent cystic fibrosis children with good clinical scores. | |
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MedLine Citation:
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PMID: 2707278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-one pre-adolescent cystic fibrosis (CF) children with good clinical scores had significant (P less than 0.001) deficiencies of arachidonic (mean 3.8% of total plasma fatty acids +/- SD 1.4) and linoleic (18.1 +/- 6.3) acids compared with controls (6.0 +/- 1.0, and 27.6 +/- 3.9, respectively). Despite the presence of pulmonary involvement of varying severity in all the CF children, neither arachidonic nor linoleic acid levels correlated significantly with pulmonary function measured by spirometry. All children had adequate caloric and fat intakes, and the coefficient of fat absorption correlated with none of the deficient fatty acid levels. These findings suggest that deficiencies of arachidonic and linoleic acids are of minor importance in the early development of pulmonary involvement in CF, and that factors other than fat malabsorption and decreased dietary intake probably contribute to fatty acid deficiency. |
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Authors:
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G N Thompson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pediatrics Volume: 148 ISSN: 0340-6199 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 1989 Jan |
Date Detail:
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Created Date: 1989-06-08 Completed Date: 1989-06-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 327-9 Citation Subset: IM |
Affiliation:
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Department of Chemical Pathology, Adelaide Children's Hospital, South Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Child, Preschool Cystic Fibrosis / blood* Dietary Fats / metabolism* Fatty Acids, Essential / blood, deficiency* Female Humans Intestinal Absorption* Lung Volume Measurements* Male |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids, Essential |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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