Document Detail


Relationships between coronary flow vasodilator capacity and small artery remodelling in hypertensive patients.
MedLine Citation:
PMID:  12640258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Arterial hypertension is frequently associated with the presence of structural alterations in small arteries. Moreover, a reduced coronary flow reserve and vasodilator capacity has been observed in essential hypertensive patients, possibly due, at least in part, to microangiopathy of small coronary vessels. The aim of the present study was to evaluate a possible relationship between subcutaneous small artery structure and coronary flow reserve or vasodilator capacity in patients with essential hypertension. METHODS AND RESULTS: A total of 20 patients with mild to moderate essential hypertension were included in the study, and underwent a biopsy of the subcutaneous fat from the gluteal region. Small arteries were dissected and mounted on a micromyograph. The media thickness, the normalized internal diameter and the media:lumen ratio (M/L) were then calculated. In addition, a transesophageal Doppler echocardiographic study, which allows the measurement of coronary flow velocity before and during maximal pharmacological vasodilatation, was performed. Coronary flow reserve (CFR) was measured as the ratio of coronary flow velocity assessed during adenosine infusion and that measured in basal conditions. From blood pressure and coronary flow velocity during adenosine infusion, minimum coronary resistance was calculated. CFR as well as minimum coronary resistance were significantly correlated to both M/L and to normalized internal diameter of subcutaneous small arteries. CONCLUSIONS: Our results are consistent with the hypothesis of a generalized remodelling of small arteries in the body, including the coronary circulation; this remodelling may play an important role in the reduction of coronary vasodilator capacity in patients with mild to moderate essential hypertension.
Authors:
Damiano Rizzoni; Carlo Palombo; Enzo Porteri; Maria Lorenza Muiesan; Michaela Kozàkovà; Giovanni La Canna; Matilde Nardi; Daniele Guelfi; Massimo Salvetti; Carmela Morizzo; Francesca Vittone; Enrico Agabiti Rosei
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  21     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-17     Completed Date:  2003-12-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  625-31     Citation Subset:  IM    
Affiliation:
Chair of Internal Medicine, Division of Cardiology, University of Brescia, c/o 2a Medicina, Spedali Civili, 25100 Brescia, Italy. rizzoni@master.cci.unibs.it
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / blood supply
Aged
Arteries / physiopathology*
Coronary Circulation / physiology
Coronary Vessels / physiopathology*
Echocardiography, Transesophageal
Female
Humans
Hypertension / physiopathology*,  ultrasonography
Male
Microcirculation / physiopathology
Middle Aged
Vascular Resistance / physiology
Vasodilation / physiology*
Comments/Corrections
Comment In:
J Hypertens. 2003 Mar;21(3):505-6   [PMID:  12640242 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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