| Relationships between common polymorphisms of adenosine triphosphate-binding cassette transporter A1 and high-density lipoprotein cholesterol and coronary heart disease in a population with type 2 diabetes mellitus. | |
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MedLine Citation:
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PMID: 19059534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with type 2 diabetes mellitus (T2D) have a high coronary risk partly because of low levels of high-density lipoprotein-cholesterol (HDL-C). The adenosine triphosphate-binding cassette transporter A1 (ABCA1) plays a key role in HDL metabolism. We studied the association of common single nucleotide polymorphisms (SNPs) in the ABCA1 gene with HDL-C levels and coronary risk in a cohort of subjects with T2D. We studied 5 SNPs: +69C>T, +378G>C, R219K, I883M, and R1587K. The C allele of +378G>C was significantly associated with lower HDL-C concentrations (P = .04); and the M allele of I883M, with higher HDL-C concentrations (P = .03). No significant association was found between these SNPs and the incidence of new coronary events. Nevertheless, cross-sectional data on entry showed that the frequency of K219 was lower in patients with previous coronary heart disease (angina pectoris and/or myocardial infarction) (odds ratio, OR [95% confidence interval, CI] = 0.80 [0.65-0.98], P = .03, after adjustment for multiple risk factors other than HDL-C). The frequency of K1587 was higher in patients with angina pectoris (OR [95% CI] = 1.27 [1.01-1.58], P = .04, after multiple adjustment). The TT genotype of the C69T SNP was less frequent in subjects with prior myocardial infarction (OR [95% CI] = 0.28 [0.13-0.61], P = .001, after multiple adjustment). These associations persisted after further adjustment for HDL-C levels. In conclusion, common genetic variations of ABCA1 had a moderate influence on HDL-C levels and/or coronary heart disease in patients with T2D. These 2 effects were independent. |
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Authors:
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Isabelle Porchay-Baldérelli; Franck Péan; Nathalie Emery; Suliya Maimaitiming; Naima Bellili; Florence Travert; Kamel Mohammedi; Ronan Roussel; Michel Marre; Frédéric Fumeron; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 58 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-08 Completed Date: 2009-01-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 74-9 Citation Subset: IM |
Affiliation:
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INSERM U695, Genetic Determinants for Type 2 Diabetes and its Vascular Complications, Xavier Bichat Medical School, 16 rue Henri Huchard, 75018 Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ATP-Binding Cassette Transporters
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genetics* Aged Alleles Cholesterol, HDL / blood* Cohort Studies Coronary Disease / blood*, complications, genetics* Cross-Sectional Studies DNA / chemistry, genetics Diabetes Mellitus, Type 2 / blood*, complications, genetics* Female Genotype Humans Logistic Models Male Polymerase Chain Reaction Polymorphism, Single Nucleotide Prevalence Prospective Studies Randomized Controlled Trials as Topic |
| Chemical | |
Reg. No./Substance:
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0/ATP binding cassette transporter 1; 0/ATP-Binding Cassette Transporters; 0/Cholesterol, HDL; 9007-49-2/DNA |
| Investigator | |
Investigator/Affiliation:
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M Marre / ; G Schernthaner / ; R Rottiers / ; V Profozic / ; J Perusicova / ; M Marre / ; J Mann / ; S Pappas / ; G Pogatsa / ; J Belkhadir / ; F Hakkou / ; J Jonker / ; G Schernthaner / ; F Hawkins / ; K Scheidegger / ; M Gueddiche / ; U Gorpe / ; G C Viberti / ; F Alhenc-Gelas / ; J P Boissel / ; F Cambien / ; S Etienne / ; A Girault-Louvel / ; P Gueret / ; M Lièvre / ; J Mann / ; M Marre / ; J Ménard / ; P Passa / ; P F Plouin / ; D Vasmant / ; L Vaur / ; G C Viberti / ; C Weisselberg / ; J P Boissel / ; M Lièvre / ; V Bost / ; M Cambien / ; Y Gallois / ; N Genes / ; J Gillet / ; M Hervé / ; M Lièvre / ; M Marre / ; L Martin / ; A Perret-Hantzperg / ; P F Plouin / ; L Vaur / ; F Alhenc-Gelas / ; F Cambien / ; A Girault-Louvel / ; M Lièvre / ; M Marre / ; J Ménard / ; E Bonnefoy / ; G Chatellier / ; T Moreau / ; L Pinède / ; E Eschwege / ; C E Mogensen / ; N Victor / ; S Weber / |
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