| Relationships between the amount of saliva and medications in elderly individuals. | |
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MedLine Citation:
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PMID: 20545772 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Gerodontology 2010; doi: 10.1111/j.1741-2358.2009.00358.x Relationships between the amount of saliva and medications in elderly individuals Objective: To investigate medications that are related to volume of saliva in the elderly. Background data: In the elderly, many cases of mouth dryness may represent side effects of medication. Materials and methods: The volume of unstimulated saliva was measured for 30 s (cotton roll test), and with stimulation for 3 min (gum test) in 368 subjects 79-80 years old (177 men, 191 women). Medications were investigated using subject's medication notebooks. Results: Mean volumes of unstimulated and stimulated saliva were 0.14 ± 0.13 and 4.30 ± 2.54 ml respectively. Significant differences were seen between gender and mean volume of saliva. The volume of unstimulated saliva was 0.16 ± 0.15 ml for men and 0.11 ± 0.10 ml for women. The volume of stimulated saliva was 4.99 ± 2.67 ml for men and 3.67 ± 2.25 ml for women. The percentage of subjects taking medication was 64.7% (238/368). Mean number of medications was 2.08 ± 2.26, with no significant difference with gender (2.01 ± 2.37 for men, 2.16 ± 2.16 for women). In a stepwise multiple regression analysis with volume of saliva as the objective variable and number of drugs by category as explanatory variables, significant explanatory variables in addition to gender and number of medications were blood-coagulating agents, Ca antagonists and peptic ulcer drugs for volume of unstimulated saliva, and diabetes medications and peptic ulcer drugs for volume of stimulated saliva. Conclusion: These findings suggest that differences exist between gender in volume of saliva for elderly individuals, and that the volume of saliva is affected by the number and type of medications. |
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Authors:
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Kana Ichikawa; Shihoko Sakuma; Akihiro Yoshihara; Hideo Miyazaki; Saori Funayama; Kayoko Ito; Atsuko Igarashi |
Publication Detail:
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Type: Journal Article Date: 2010-06-02 |
Journal Detail:
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Title: Gerodontology Volume: 28 ISSN: 1741-2358 ISO Abbreviation: Gerodontology Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8215850 Medline TA: Gerodontology Country: England |
Other Details:
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Languages: eng Pagination: 116-20 Citation Subset: D |
Copyright Information:
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© 2010 The Gerodontology Society and John Wiley & Sons A/S. |
Affiliation:
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Department of Oral Health and Welfare, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan Niigata University Medical and Dental Hospital Preventive Dentistry, Niigata, Japan Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan Niigata University Medical and Dental Hospital Geriatric Dentistry, Niigata, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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