| Relationships between adipose tissue and cytokine responses to a randomized controlled exercise training intervention. | |
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MedLine Citation:
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PMID: 18328363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adipose-derived cytokines play a prominent role in mediating the metabolic consequences of obesity and excess body fat. Given this, we hypothesized that alterations in adipose tissue stores incurred with exercise training would be reflected in changes in systemic cytokine concentrations. The Studies of Targeted Risk Reduction Intervention through Defined Exercise, where pronounced changes in adipose tissue stores were observed in the absence of significant changes in dietary intake, provided an ideal setting in which to test this hypothesis. Participants were randomized to 6 months of inactivity or one of 3 types of aerobic exercise training regimens: low-amount-moderate-intensity, low-amount-vigorous-intensity, and high-amount-vigorous-intensity. Plasma samples were collected at baseline and 2 weeks after cessation of 6 months of exercise training or inactivity. In 189 participants, concentrations of 17 cytokines were measured using Bio-Plex Cytokine Assays (Bio-Rad, Hercules, CA); 10 additional cytokines were measured in 60 of these subjects. Of all cytokines tested, the only concentration changes that approached statistical significance were those for granulocyte monocyte-colony stimulating factor and vascular endothelial growth factor, which appeared to increase with training in the low-amount-high-intensity group only (P < .05 for both cytokines). No response to exercise training was noted for any additional cytokine in any of the groups. No relationships were observed between changes in cytokine concentrations and changes in fat mass or other measures of body habitus. In contradiction to our hypothesis, despite significant alterations in body composition, exercise training produced limited cytokine responses. |
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Authors:
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Kim M Huffman; Cris A Slentz; Connie W Bales; Joseph A Houmard; William E Kraus |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 57 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-10 Completed Date: 2008-04-15 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 577-83 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. huffm007@mc.duke.edu <huffm007@mc.duke.edu> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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anatomy & histology* Adult Aged Body Composition* C-Reactive Protein / analysis Cytokines / blood* Exercise* Female Humans Male Middle Aged Obesity / immunology, metabolism, therapy* |
| Grant Support | |
ID/Acronym/Agency:
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AG028930-01/AG/NIA NIH HHS; P30 AG028716-019001/AG/NIA NIH HHS; P30 AGO28716-01//PHS HHS; R01 AG028930-01/AG/NIA NIH HHS; R01 HL057354-05/HL/NHLBI NIH HHS; R01HL-57354/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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