Document Detail


Relationships among participant international prostate symptom score, benign prostatic hyperplasia impact index changes and global ratings of change in a trial of phytotherapy in men with lower urinary tract symptoms.
MedLine Citation:
PMID:  23017510     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: We related changes in American Urological Association symptom index scores with bother measures and global ratings of change in men with lower urinary tract symptoms who were enrolled in a saw palmetto trial.
MATERIALS AND METHODS: To be eligible for study men were 45 years old or older, and had a peak uroflow of 4 ml per second or greater and an American Urological Association symptom index score of 8 to 24. Participants self-administered the American Urological Association symptom index, International Prostate Symptom Score quality of life item, Benign Prostatic Hyperplasia Impact Index and 2 global change questions at baseline, and at 24, 48 and 72 weeks.
RESULTS: In 357 participants global ratings of a little better were associated with a mean decrease in American Urological Association symptom index scores from 2.8 to 4.1 points across 3 time points. The analogous range for mean decreases in Benign Prostatic Hyperplasia Impact Index scores was 1.0 to 1.7 points and for the International Prostate Symptom Score quality of life item it was 0.5 to 0.8 points. At 72 weeks for the first global change question each change measure discriminated between participants who rated themselves at least a little better vs unchanged or worse 70% to 72% of the time. A multivariate model increased discrimination to 77%. For the second global change question each change measure correctly discriminated ratings of at least a little better vs unchanged or worse 69% to 74% of the time and a multivariate model increased discrimination to 79%.
CONCLUSIONS: Changes in American Urological Association symptom index scores could discriminate between participants rating themselves at least a little better vs unchanged or worse. Our findings support the practice of powering studies to detect group mean differences in American Urological Association symptom index scores of at least 3 points.
Authors:
Michael J Barry; Alan Cantor; Claus G Roehrborn;
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-09-24
Journal Detail:
Title:  The Journal of urology     Volume:  189     ISSN:  1527-3792     ISO Abbreviation:  J. Urol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-11     Completed Date:  2013-06-11     Revised Date:  2014-04-11    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  987-92     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Humans
Lower Urinary Tract Symptoms / diagnosis*,  etiology
Male
Middle Aged
Phytotherapy / methods*
Plant Preparations / therapeutic use*
Prostatic Hyperplasia / complications,  diagnosis*,  drug therapy
Questionnaires
Severity of Illness Index
Treatment Outcome
Urination / drug effects,  physiology*
Grant Support
ID/Acronym/Agency:
U01 DK063788/DK/NIDDK NIH HHS; U01 DK63778/DK/NIDDK NIH HHS; U01 DK63788/DK/NIDDK NIH HHS; U01 DK63795/DK/NIDDK NIH HHS; U01 DK63797/DK/NIDDK NIH HHS; U01 DK63825/DK/NIDDK NIH HHS; U01 DK63831/DK/NIDDK NIH HHS; U01 DK63833/DK/NIDDK NIH HHS; U01 DK63835/DK/NIDDK NIH HHS; U01 DK63840/DK/NIDDK NIH HHS; U01 DK63862/DK/NIDDK NIH HHS; U01 DK63866/DK/NIDDK NIH HHS; U01 DK63883/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Plant Preparations
Investigator
Investigator/Affiliation:
Michael J Barry / ; O Dale Williams / ; Sreeletha Meleth / ; Alan Cantor / ; Andrew McCullough / ; Christopher Kelly / ; Brianne Goodwin / ; Laurie Mantor / ; Artrit Butuci / ; Andrew L Avins / ; Harley Goldberg / ; Luisa Hamilton / ; Cynthia Huynh / ; Kevin T McVary / ; Robert Brannigan / ; Brian Helfand / ; Maria Velez / ; Nancy Schoenecker / ; J Curtis Nickel / ; Alvaro Morales / ; D Robert Siemens / ; Joe Downey / ; Janet Clark-Pereira / ; E David Crawford / ; Shandra S Wilson / ; Paul D Maroni / ; Patricia DeVore / ; Cliff Jones / ; Karl J Kreder / ; Victoria Sharp / ; Diane Meyerholz / ; Mary Eno / ; Michael J Naslund / ; Ganine Markowitz-Chrystal / ; Claus G Roehrborn / ; Brad Hornberger / ; Allison Beaver / ; Suzie Carter / ; Gerald L Andriole / ; Vivien Gardner / ; Karen Whitmore / ; Steven A Kaplan / ; Alexis E Te / ; Noreen Buckley / ; Maritza Rodriquez / ; Harris E Foster / ; John W Colberg / ; Karen Stavris / ; Jeannette Y Lee / ; John W Kusek / ; Leroy M Nyberg / ; Catherine M Meyers / ; Joseph M Betz / ; Timothy J Wilt / ; Harry H S Fong / ; Glenn S Gerber / ; Mikel Gray / ; Freddie Ann / ; Gary Koch / ; Mark Litwin / ; Warren E Lux / ; Michael P O'Leary / ; James E Williams / ; Domenic Reda /
Comments/Corrections

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