Document Detail


Relationships between maternal ethnicity, gestational age, birth weight, weight gain, and severe retinopathy of prematurity.
MedLine Citation:
PMID:  23351601     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To develop an algorithm that allows advanced identification of infants requiring treatment for retinopathy of prematurity (ROP).
STUDY DESIGN: A retrospective observational study was performed at 2 tertiary neonatal units serving a multiethnic population in the UK, using data on 929 infants eligible for ROP screening. The relationships between study variables and the risk of developing ROP requiring treatment were analyzed using multiple logistic regression.
RESULTS: After applying exclusion criteria, data from 589 infants were analyzed; of these, 57 required laser treatment. The proportion of treated infants was 5.9% of those born to black mothers, 9.39% of those born to white mothers, and 12.8% of those born to Asian mothers (P = .047). Multiple logistic regression showed that gestational age, birth weight, maternal ethnicity, and early weight gain were predictors for the development of ROP requiring treatment, with maternal ethnicity having greater predictive power compared with early weight gain. We developed an algorithm for predicting the development of ROP requiring treatment with sensitivity, specificity, and positive and negative predictive values of 100%, 65.7%, 23.8%, and 100%, respectively.
CONCLUSION: Gestational age, birth weight, early weight gain, and maternal ethnicity are important predictors for the development of ROP requiring treatment. In a multiethnic population, an algorithm to predict development of ROP requiring treatment should include maternal ethnicity. If confirmed through prospective studies, this algorithm could reduce the number of opthalmologic examinations performed for ROP screening.
Authors:
Shahid M Husain; Ajay K Sinha; Catey Bunce; Puneet Arora; Wilson Lopez; Kwok S Mun; M Ashwin Reddy; Gillian G W Adams
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-23
Journal Detail:
Title:  The Journal of pediatrics     Volume:  163     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-26     Completed Date:  2013-09-03     Revised Date:  2014-01-13    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group*
Algorithms
Asian Continental Ancestry Group*
Birth Weight*
European Continental Ancestry Group*
Female
Gestational Age*
Humans
Infant
Infant, Newborn
Mothers
Retinopathy of Prematurity / diagnosis*,  therapy
Retrospective Studies
Severity of Illness Index
Weight Gain*
Comments/Corrections
Erratum In:
J Pediatr. 2013 Dec;163(6):1798

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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