| The Relationships between Erythrocyte Membrane n-6 to n-3 Polyunsaturated Fatty Acids Ratio and Blood Lipids and C-reactive Protein in Chinese Adults: An Observational Study. | |
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MedLine Citation:
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PMID: 21784308 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the relationships between erythrocyte membrane n-6:n-3 PUFAs ratio and blood lipids and high sensitivity C-reactive protein (hs-CRP). METHODS: The observational study consisted of a population-based cross-sectional study of 456 Chinese and a subsequent 1-year follow-up study of 171 subjects with the fasting plasma total cholesterol of 5.13-8.00 mmol/L. RESULTS: In the cross-sectional analysis, plasma low-density lipoprotein cholesterol (LDL-c) had a significant and negative association with the erythrocyte membrane n-6:n-3 PUFAs ratio (P for trend=0.019) after adjusting for sex, age and total PUFA percentage. In the follow-up study, 171 subjects were categorized into quartiles by the changes of n-6:n-3 ratio in erythrocyte membrane (Δ=month 12-month 0). In the top quartile whose ratios of n-6:n-3 increased by an average of 1.25 during the follow-up, the LDL-c-lowering extent was 3.3 times of that in the lowest quartile whose ratios of n-6:n-3 decreased by an average of 1.13 (-1.07 mmol/L v.s. -0.32 mmol/L). The hsCRP decreased by 0.11 mg/dL in the lowest quartile while increasing by 0.10 mg/dL in the top quartile (P for difference=0.052). CONCLUSION: Our results suggested that the balance between n-6 and n-3 fatty acids may optimize the cardiovascular benefits from dietary PUFAs. |
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Authors:
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Bo Zhang; Ping Wang; Quan Zhou; Chaogang Chen; Shuyu Zhuo; Yanbin Ye; Qiqiang He; Yuming Chen; Yixiang Su |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomedical and environmental sciences : BES Volume: 24 ISSN: 0895-3988 ISO Abbreviation: Biomed. Environ. Sci. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-07-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8909524 Medline TA: Biomed Environ Sci Country: United States |
Other Details:
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Languages: eng Pagination: 234-42 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 The Editorial Board of Biomedical and Environmental Sciences. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Faculty of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, Guangdong, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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