| Relationships between circulating adiponectin levels and fat distribution in obese subjects. | |
| | |
MedLine Citation:
|
PMID: 21378472 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: Most studies have reported that circulating levels of adiponectin are negatively correlated with the body mass index (BMI), and hypoadiponectinemia is related to cardiometabolic disorders; however, not all obese subjects have hypoadiponectinemia. The present study investigated circulating adiponectin levels and fat distribution, i.e. subcutaneous fat area (SFA) and visceral fat area (VFA), in obese subjects. METHODS: Sixty-eight obese Korean subjects underwent fat distribution by computed tomography (CT) scan and laboratory tests including circulating total adiponectin levels (APN) and circulating high molecular weight adiponectin levels (HMW-APN). RESULTS: Log-APN and log-HMW-APN did not correlate with log-BMI either in obese males or females in this study; however, log-APN significantly and negatively correlated with log-VFA both in obese males (r=-0.691, p=0.009) and females (r=-0.319, p=0.002), and log-HMW-APN also correlated negatively with log-VFA both in obese males (r=-0.650, p=0.016) and females (r=-0.370, p=0.005). Log-VFA was a significant determinant of log-APN and log-HMW-APN in obese subjects. In contrast, neither log-APN nor log-HMW-APN was significantly correlated with log-SFA in obese males and females. CONCLUSIONS: The present study demonstrated that APN and HMW-APN correlated with VFA, but not BMI and SFA, in obese subjects, and suggest that hypoadiponectinemia may represent dysfunction of adipose tissue in obesity. |
| | |
Authors:
|
Ken Kishida; Kyoung Kon Kim; Tohru Funahashi; Yuji Matsuzawa; Hee-Cheol Kang; Iichiro Shimomura |
Publication Detail:
|
Type: Journal Article Date: 2011-03-03 |
Journal Detail:
|
Title: Journal of atherosclerosis and thrombosis Volume: 18 ISSN: 1880-3873 ISO Abbreviation: J. Atheroscler. Thromb. Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-07-22 Completed Date: 2011-12-14 Revised Date: 2011-12-15 |
Medline Journal Info:
|
Nlm Unique ID: 9506298 Medline TA: J Atheroscler Thromb Country: Japan |
Other Details:
|
Languages: eng Pagination: 592-5 Citation Subset: IM |
Affiliation:
|
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adiponectin
/
blood* Adipose Tissue / metabolism Adult Body Composition Body Mass Index Coronary Disease / blood Female Gene Expression Regulation Humans Korea Male Middle Aged Multivariate Analysis Obesity / blood* Tomography, X-Ray Computed / methods |
| Chemical | |
Reg. No./Substance:
|
0/Adiponectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: [A ten-year follow-up of a 109-year-old woman with myocardial infarction].
Next Document: Association between Non-High-Density Lipoprotein Cholesterol Levels and the Incidence of Coronary He...