| Relationships among rhinitis, fibromyalgia, and chronic fatigue. | |
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MedLine Citation:
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PMID: 20615318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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New information about the pathophysiology of idiopathic nonallergic rhinopathy indicates a high prevalence in chronic fatigue syndrome (CFS). This article shows the relevance of CFS and allied disorders to allergy practice. CFS has significant overlap with systemic hyperalgesia (fibromyalgia), autonomic dysfunction (irritable bowel syndrome and migraine headaches), sensory hypersensitivity (dyspnea; congestion; rhinorrhea; and appreciation of visceral nociception in the esophagus, gastrointestinal tract, bladder, and other organs), and central nervous system maladaptations (central sensitization) recorded by functional magnetic resonance imaging (fMRI). Neurological dysfunction may account for the overlap of CFS with idiopathic nonallergic rhinopathy. Scientific advances are in fMRI, nociceptive sensor expression, and, potentially, infection with xenotropic murine leukemia-related virus provide additional insights to novel pathophysiological mechanisms of the "functional" complaints of these patients that are mistakenly interpreted as allergic syndromes. As allergists, we must accept the clinical challenges posed by these complex patients and provide proper diagnoses, assurance, and optimum care even though current treatment algorithms are lacking. |
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Authors:
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James N Baraniuk; Yin Zheng |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Allergy and asthma proceedings : the official journal of regional and state allergy societies Volume: 31 ISSN: 1539-6304 ISO Abbreviation: Allergy Asthma Proc Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-07-09 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9603640 Medline TA: Allergy Asthma Proc Country: United States |
Other Details:
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Languages: eng Pagination: 169-78 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, Immunology and Allergy, Georgetown University, PHC Building, 3800 Reservoir Road, NW, Washington, DC 20007-2197, USA. baraniuj@georgetown.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diagnosis, Differential Fatigue Syndrome, Chronic / diagnosis*, etiology, pathology, physiopathology Fibromyalgia Humans Irritable Bowel Syndrome Leukemia Virus, Murine / immunology*, pathogenicity Magnetic Resonance Imaging Mice Nociceptors / pathology Practice Guidelines as Topic Retroviridae Infections / complications, diagnosis*, pathology, physiopathology Rhinitis Sensation Disorders |
| Grant Support | |
ID/Acronym/Agency:
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M01RR-023942/RR/NCRR NIH HHS; R01 ES015382/ES/NIEHS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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