| Relationships of CRP and P wave dispersion with atrial fibrillation in hypertensive subjects. | |
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MedLine Citation:
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PMID: 19942863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although inflammation has been shown to be implicated in the pathophysiology of atrial fibrillation (AF), little is known about its involvement in the accompanying atrial electrical remodeling expressed by P wave dispersion (P(disp)). METHODS: Fifty hypertensive subjects with documented paroxysmal AF (AF group) and 50 matched for body mass index, sex and office systolic blood pressure (BP) subjects with no history of AF (SR group) were subjected to electrocardiogram (ECG) and P(disp) assessment, hs-CRP determination, a complete echocardiographic study and 24-h ambulatory BP monitoring. RESULTS: The AF as compared to the SR subjects were older by 14 years (P < 0.0001) and they exhibited lower office and 24-h diastolic BP (7 mm Hg, P < 0.0001 and by 8 mm Hg, P < 0.0001, respectively) and higher office and 24-h pulse pressure (by 4 mm Hg, P = 0.03 and 6 mm Hg, P = 0.001, respectively) mean values. A higher mean of left atrial (LA) diameter index (by 1.9 mm/m(2), P < 0.0001) and left ventricular mass index (by 16 g/m(2), P < 0.0001) were observed in the AF vs. SR group. P(disp) mean and hs-CRP median values were higher in the AF group (by 22 ms, P < 0.0005 and by 4.63 mg/l, P < 0.0005, respectively). Standard multiple and multiple logistic regression analysis identified log(10)(hs-CRP) as independent determinant of P(disp) and log(10)(CRP) and P(disp) as independent determinants of AF. CONCLUSIONS: In hypertensive subjects hs-CRP and P(disp) are interrelated and associated with AF, suggesting an active implication of inflammation in the atrial electrophysiological remodeling predisposing to AF. |
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Authors:
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Costas Tsioufis; Dimitris Syrseloudis; Awalia Hatziyianni; Vanessa Tzamou; Ioannis Andrikou; Panaglotis Tolis; Kostas Toutouzas; Andreas Michaelidis; Christodoulos Stefanadis |
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Publication Detail:
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Type: Journal Article Date: 2009-11-26 |
Journal Detail:
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Title: American journal of hypertension Volume: 23 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-20 Completed Date: 2010-03-09 Revised Date: 2011-06-30 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 202-7 Citation Subset: IM |
Affiliation:
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First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Atrial Fibrillation / blood*, etiology, physiopathology* Blood Pressure / physiology Blood Pressure Monitoring, Ambulatory Body Mass Index C-Reactive Protein / metabolism* Cross-Sectional Studies Echocardiography Electrocardiography Electrophysiology Female Humans Hypertension / blood*, complications, physiopathology* Linear Models Male Middle Aged Myocardial Contraction / physiology Pulsatile Flow / physiology |
| Chemical | |
Reg. No./Substance:
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9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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