| Relationships Among Multifocal Electroretinogram Amplitude, Visual Field Sensitivity, and SD-OCT Receptor Layer Thicknesses in Patients with Retinitis Pigmentosa. | |
| | |
MedLine Citation:
|
PMID: 22247460 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Purpose.To compare local functional measures, the multifocal electroretinogram (mfERG) and visual field sensitivity, to a local structural measure, spectral domain optical coherence tomography (SD-OCT), of receptor damage in patients with retinitis pigmentosa (RP).Methods.MfERGs, visual fields and SD-OCT scans were obtained from 10 patients with RP, ranging in age from 23 to 59 years. Average amplitudes, average linear sensitivities, and average layer thicknesses were measured from within the central 3° and from three concentric annuli located between 3 to 8°, 8 to 15°, and 15 to 24°. A computer program aided manual segmentation and calculated OCT thickness in the scans.Results.Within each patient with RP, mfERG amplitude for each circle/annulus was highly correlated with corresponding layer thicknesses in the outer retina (r = 0.88 to 0.99), but not at all correlated with thickness of the inner nuclear layer or total retina. Across all ring eccentricities, relative mfERG amplitude and relative visual field sensitivity were correlated with relative SD-OCT outer retinal thickness.Conclusions.In patients with RP, preserved cone photoreceptor function measured by mfERG amplitude and visual field sensitivity correlate well with the remaining thickness of the photoreceptor layer. All three measures show comparable relative loss beyond 3° eccentricity. In the fovea, SD-OCT outer retina thickness showed less relative loss than either mfERG or visual field sensitivity. |
| | |
Authors:
|
Yuquan Wen; Martin Klein; Donald C Hood; David G Birch |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-12 |
Journal Detail:
|
Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Retina Foundation of the Southwest, Dallas, TX; |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Myofibroblast differentiation modulates keratocyte crystallin protein expression, concentration, and...
Next Document: Asymmetry in hemifield macular thickness as an early indicator of glaucomatous change.