| Relationship of visceral and subcutaneous adiposity with renal function in people with type 2 diabetes mellitus. | |
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MedLine Citation:
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PMID: 21030458 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Obesity and diabetes mellitus (DM) are established risk factors for the development of chronic kidney disease. Visceral adiposity (VAT) and subcutaneous adiposity (SAT) may be associated with the differential metabolic risk. Our study was performed to determine whether VAT or SAT was associated with the decrease of renal function in people with type 2 DM. METHODS: Nine hundred and twenty-nine people with type 2 DM and who had undergone abdominal computed tomography assessment of the SAT and VAT areas were included. The estimated glomerular filtration rate (eGFR) was calculated using the Cockcroft-Gault equation and the Modification of Diet in Renal Disease (MDRD) four-variable equation at the time of the assessment of the SAT and VAT areas. RESULTS: VAT was negatively associated with eGFR using the MDRD equation after adjustment for the clinical variables (β-coefficient = - 0.075, P = 0.034), while SAT was not significantly associated with eGFR. There was no significant association between the abdominal adiposity measurements and the eGFR using the Cockcroft-Gault formula. When stratifying the individuals by the body mass index groups, VAT was negatively associated with eGFR by the MDRD equation and the Cockcroft-Gault formula in the overweight and obese subjects after adjustment for the clinical variables, while there was no significant association between the VAT and the eGFR in the normal weight subjects. SAT was not significantly associated with eGFR in the normal weight, overweight and obese subjects. CONCLUSIONS: Our data suggest that VAT may be an additional prognostic factor for the decrease of renal function especially in the overweight or obese subjects with type 2 DM. |
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Authors:
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Sung Rae Kim; Ji Han Yoo; Ho Cheol Song; Seong Su Lee; Soon Jib Yoo; Young-Du Kim; Yeon Soo Lim; Hyung Wook Kim; Chul Woo Yang; Yong-Soo Kim; Euy Jin Choi; Yong Kyun Kim |
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Publication Detail:
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Type: Journal Article Date: 2010-10-28 |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 26 ISSN: 1460-2385 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
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Languages: eng Pagination: 3550-5 Citation Subset: IM |
Affiliation:
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Correspondence and offprint requests to: Yong Kyun Kim; E-mail: drkimyk@catholic.ac.kr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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