| Relationship of type 1 diabetes to ancestral proportions and HLA DR/DQ alleles in a sample of the admixed Cuban population. | |
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MedLine Citation:
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PMID: 20569042 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Incidence of type 1 diabetes varies widely around the world, probably due to ethnic differences across populations among other factors. AIMS: To determine whether there is an association between disease and ancestry proportions; and to control disease-HLA associations for possible confounding by admixture or population stratification. SUBJECTS AND METHODS: 100 cases and 129 controls participated in the study. Ancestry informative markers, which have considerable differences in frequency between European, West African and Native American populations were used. Type 1 diabetes associated HLA susceptibility/protection alleles were ascertained by PCR using specific primers. Statistical analyses were conducted using STRUCTURE 2.1, ADMIXMAP 3.7, SPSS 16.0 and STRAT 1.0 packages. RESULTS: The results of logistic regression implemented in ADMIXMAP 3.7 indicated that European ancestry was associated with type 1 diabetes mellitus with an odds ratio of 5.7 corresponding to one unit change in European admixture proportion. Association was found between HLA alleles and disease, DQA1*0501, *0301 DQB1*0201 and DRB1*0301, *0401 being susceptibility alleles and DRB1*1501, DQA1*0102/3 and DQB1*0602 being protective alleles. CONCLUSIONS: We found an association between European ancestry and type 1 diabetes in our sample, indicating the contribution of ethnicity to incidence differences. Previously reported associations of HLA DR/DQ alleles with disease are confirmed for the admixed Cuban population. |
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Authors:
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Oscar Diaz-Horta; Alberto Cintado; Maria Elena Fernandez-De-Cossio; Marcelo Nazabal; Annia Ferrer; Juan Roca; Hamlet Camacho; Jesus Benítez; Mayte Ale; Adelaida Villarreal; Gisela Molina; Manuel Vera; Eduardo Cabrera-Rode; Lidia Novoa |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-22 |
Journal Detail:
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Title: Annals of human biology Volume: 37 ISSN: 1464-5033 ISO Abbreviation: Ann. Hum. Biol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404024 Medline TA: Ann Hum Biol Country: England |
Other Details:
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Languages: eng Pagination: 778-88 Citation Subset: IM |
Affiliation:
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Departamento de Inmunologia y Genetica de la Diabetes, Instituto Nacional de Endocrinología, Zapata y D, Havana, Cuba. odiazor@infomed.sld.cu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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