Document Detail


Relationship of timing of agonist administration in the cycle phase to the ovarian response to gonadotropins in the long down-regulation protocols for assisted reproductive technologies.
MedLine Citation:
PMID:  8557125     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess whether the ovarian response to exogenous gonadotropins and cycle performance is affected by different timing of an agonist administration in long down-regulation protocols. DESIGN: An agonist was administered irrespective of cycle phase, with exogenous gonadotropin beginning 15 days later. PATIENTS: Five hundred fifty-seven normovulatory infertile patients, aged < or = 38 years, were classified into seven study groups, depending on the phase of the cycle in which agonist was started. MAIN OUTCOME MEASURES: Endocrine profile, amount of exogenous stimulation, occurrence of ovarian cysts, mean number of oocytes recovered and embryos transferred, pregnancy rate, implantation rate, and live-birth rate of the seven groups. RESULTS: The ovarian response of the groups did not show any statistically significant differences in relation to the initiation of the agonist. The only effect was a different incidence of ovarian cyst formation, but this phenomenon did not affect cycle performance. The pregnancy, implantation, and live-birth rates showed differences that did not reach statistical significance. CONCLUSION: Agonists initiation can be programmed in advance irrespective of the phase of the cycle. This approach can be of help for the logistics of assisted reproduction programs.
Authors:
A P Ferraretti; C Magli; E Feliciani; N Montanaro; L Gianaroli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  65     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-02-27     Completed Date:  1996-02-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  114-21     Citation Subset:  IM    
Affiliation:
Reproductive Medicine Unit, Società Italiana per gli Studi sulla Medicina della Riproduzione srl, Bologna, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Buserelin / pharmacology*
Embryo Transfer*
Female
Fertilization in Vitro*
Follicle Stimulating Hormone / pharmacology
Humans
Menotropins / pharmacology
Ovarian Cysts / etiology
Ovary / drug effects*
Pregnancy
Time Factors
Chemical
Reg. No./Substance:
57982-77-1/Buserelin; 61489-71-2/Menotropins; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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