| Relationship of temporal resolution to diagnostic performance for dynamic contrast enhanced MRI of the breast. | |
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MedLine Citation:
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PMID: 19856413 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the relationship between temporal resolution of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and classification of breast lesions as benign versus malignant. MATERIALS AND METHODS: Patients underwent T(1)-weighted DCE MRI with 15 s/acquisition temporal resolution using 1.5 Tesla (n = 48) and 3.0T (n = 33) MRI scanners. Seventy-nine patients had pathologically proven diagnosis and 2 had 2 years follow-up showing no change in lesion size. The temporal resolution of DCE MRI was systematically reduced as a postprocessing step from 15 to 30, 45, and 60 s/acquisition by eliminating intermediate time points. Average wash-in and wash-out slopes, wash-out percentage changes, and kinetic curve shape (persistently enhancing, plateau, or wash-out) were compared for each temporal resolution. Logistic regression and receiver operating characteristic (ROC) curve analysis were used to compare kinetic parameters and diagnostic accuracy. RESULTS: Sixty patients (74%) had malignant lesions and 21 patients (26%) had benign lesions. All temporal-resolution parameters significantly predicted benign versus malignant diagnosis (P < 0.05). However, 45 s/acquisition and higher temporal-resolution datasets showed higher accuracy than the 60 s/acquisition dataset by ROC curve analysis (0.72 versus 0.69 for average wash-in slope; 0.85 versus 0.82, for average wash-out slope; and 0.88 versus 0.80 for kinetic curve shape assessment, for 45 s/acquisition versus 60 s/acquisition temporal-resolution datasets, respectively (P = 0.027). CONCLUSION: DCE MRI data with at least 45-s temporal resolution maximized the agreement between the kinetic parameters and correct classification of benign versus malignant diagnosis. |
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Authors:
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Riham H El Khouli; Katarzyna J Macura; Peter B Barker; Mohamed R Habba; Michael A Jacobs; David A Bluemke |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 30 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-29 Completed Date: 2010-01-21 Revised Date: 2011-06-09 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 999-1004 Citation Subset: IM |
Affiliation:
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National Institutes of Health, Department of Radiology and Imaging Sciences, Bethesda, Maryland, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Area Under Curve Breast / pathology* Contrast Media / pharmacology* Female Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods Kinetics Magnetic Resonance Imaging / methods* Middle Aged Reproducibility of Results Retrospective Studies Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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1R01CA100184/CA/NCI NIH HHS; P50CA103175/CA/NCI NIH HHS; R01 CA100184-01A2/CA/NCI NIH HHS; R01 CA100184-02/CA/NCI NIH HHS; R01 CA100184-04S3/CA/NCI NIH HHS; R01 CA125258-03/CA/NCI NIH HHS; R01 CA125258-05/CA/NCI NIH HHS; R01CA125258/CA/NCI NIH HHS; ZIA EB000065-01/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
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