Document Detail


RELATIONSHIP OF STRUCTURE TO FUNCTION IN BACTERIAL O ANTIGENS. III. BIOLOGICAL PROPERTIES OF ENDOTOXOIDS.
MedLine Citation:
PMID:  14137617     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Johnson, Arthur G. (The University of Michigan, Ann Arbor), and Alois Nowotny. Relationship of structure to function in bacterial O antigens. III. Biological properties of endotoxoids. J. Bacteriol. 87:809-814. 1964.-Endotoxin (somatic O antigen) was rendered much less lethal for mice and rabbits after treatment with boron trifluoride, potassium methylate, or pyridinium formate. In addition, the ability to induce the second fever peak of the biphasic febrile response characteristic of endotoxin was abolished. The capacity to prepare for the local Shwartzman reaction was also reduced after such treatments. On the other hand, stimulation of nonspecific resistance, and adjuvant action in mice was retained. The ability to elicit specific antibody was diminished after boron trifluoride treatment but only slightly retarded by the other two procedures.
Authors:
A G JOHNSON; A NOWOTNY
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bacteriology     Volume:  87     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1964 Apr 
Date Detail:
Created Date:  1964-08-01     Completed Date:  1996-12-01     Revised Date:  2011-09-28    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  809-14     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Antibody Formation*
Antigen-Antibody Reactions*
Antigens*
Endotoxins*
Hypotension*
Mice*
Pyrogens*
Rabbits*
Research*
Serratia marcescens*
Shwartzman Phenomenon*
Toxicology*
gamma-Globulins*
Chemical
Reg. No./Substance:
0/Antigens; 0/Endotoxins; 0/Pyrogens; 0/gamma-Globulins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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