Document Detail

Relationship of sodium bicarbonate to intraventricular hemorrhage in premature infants with respiratory distress syndrome.
MedLine Citation:
PMID:  6903914     Owner:  NLM     Status:  MEDLINE    
It has been suggested that hypertonic loads of saline built up in the administration of sodium bicarbonate to correct acidosis in infants with respiratory distress syndrome (IRDS) can precipitate intraventricular hemorrhage (IVH). Therefore, from medical records we noted the daily intake of sodium of 36 babies with IRDS who were on mechanical respirators. Eighteen of the infants developed IVH, and for these infants total sodium intake 24 hours prior to IVH was also recorded. The mean was 5.83 +/- 4.22 mEq/kg per day, a dose substantially less than the recommended limit of 8 mEq/kg per day. The difference between means was not significant (p = .071), but the variance was significant (p = .016). The results indicated that the total sodium dose, particularly that taken in during the sodium bicarbonate administration, did not regularly contribute to the development of IVH, when given under controlled conditions, that is, conservative doses, dilution, and slow injection to minimize the hypertonic load.
E M Reichert; P W Fuller
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nursing research     Volume:  29     ISSN:  0029-6562     ISO Abbreviation:  Nurs Res     Publication Date:    1980 Nov-Dec
Date Detail:
Created Date:  1981-01-29     Completed Date:  1981-01-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376404     Medline TA:  Nurs Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  357-61     Citation Subset:  AIM; IM; N    
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MeSH Terms
Bicarbonates / adverse effects*
Cerebral Hemorrhage / chemically induced*
Cerebral Ventricles
Gestational Age
Infant, Newborn
Infant, Premature, Diseases / chemically induced*
Respiratory Distress Syndrome, Newborn / drug therapy*
Retrospective Studies
Sodium / adverse effects*,  blood
Grant Support
Reg. No./Substance:
0/Bicarbonates; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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