| Relationship of small gestational sac-crown-rump length differences to abortion and abortus karyotypes. | |
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MedLine Citation:
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PMID: 1553175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We retrospectively reviewed ultrasound findings in 539 infertility patients to evaluate the incidence of small gestational sac syndrome and its association with abortion, karyotype of the abortus, and known abortion factors. Small gestational sac syndrome (gestational sac diameter minus crown-rump length less than 5 mm) occurred in 1.9% of pregnancies scanned with vaginal ultrasound 37-65 days after the first day of the last menstrual period. The rate of fetal death was 80.0% when the gestational sac diameter-crown-rump length difference was less than 5 mm, 26.5% when the difference was 5-7.9 mm (P less than .002 compared with less than 5 mm), and 10.6% when the difference was 8 mm or more (P less than .0001 compared with less than 5 mm). Karyotypes were normal in all eight fetuses when the gestational sac diameter-crown-rump length difference was less than 5 mm (P less than .03). Small gestational sac syndrome was present before fetal death in 10.7% of all cases, and in 24% in which the karyotype was normal. Of the factors analyzed--maternal age, previous abortions, low hCG or progesterone levels, and use of ovulation induction medications--only maternal age was significantly different (P = .011) in patients with small sac syndrome. We conclude that small gestational sac syndrome is an infrequent but important complication of early pregnancy, which occurs more often in karyotypically normal than in abnormal fetuses. |
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Authors:
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R P Dickey; T T Olar; S N Taylor; D N Curole; E M Matulich |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 79 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-04-24 Completed Date: 1992-04-24 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 554-7 Citation Subset: AIM; IM |
Affiliation:
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Fertility Institute of New Orleans, Louisiana. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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epidemiology*,
genetics Adult Chromosome Aberrations* Extraembryonic Membranes / ultrasonography* Female Fetal Diseases / epidemiology*, genetics, ultrasonography Fetus / anatomy & histology* Humans Incidence Karyotyping Maternal Age Pregnancy Retrospective Studies Ultrasonography, Prenatal* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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