Document Detail

Relationship of small gestational sac-crown-rump length differences to abortion and abortus karyotypes.
MedLine Citation:
PMID:  1553175     Owner:  NLM     Status:  MEDLINE    
We retrospectively reviewed ultrasound findings in 539 infertility patients to evaluate the incidence of small gestational sac syndrome and its association with abortion, karyotype of the abortus, and known abortion factors. Small gestational sac syndrome (gestational sac diameter minus crown-rump length less than 5 mm) occurred in 1.9% of pregnancies scanned with vaginal ultrasound 37-65 days after the first day of the last menstrual period. The rate of fetal death was 80.0% when the gestational sac diameter-crown-rump length difference was less than 5 mm, 26.5% when the difference was 5-7.9 mm (P less than .002 compared with less than 5 mm), and 10.6% when the difference was 8 mm or more (P less than .0001 compared with less than 5 mm). Karyotypes were normal in all eight fetuses when the gestational sac diameter-crown-rump length difference was less than 5 mm (P less than .03). Small gestational sac syndrome was present before fetal death in 10.7% of all cases, and in 24% in which the karyotype was normal. Of the factors analyzed--maternal age, previous abortions, low hCG or progesterone levels, and use of ovulation induction medications--only maternal age was significantly different (P = .011) in patients with small sac syndrome. We conclude that small gestational sac syndrome is an infrequent but important complication of early pregnancy, which occurs more often in karyotypically normal than in abnormal fetuses.
R P Dickey; T T Olar; S N Taylor; D N Curole; E M Matulich
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  79     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-04-24     Completed Date:  1992-04-24     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  554-7     Citation Subset:  AIM; IM    
Fertility Institute of New Orleans, Louisiana.
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MeSH Terms
Abortion, Spontaneous / epidemiology*,  genetics
Chromosome Aberrations*
Extraembryonic Membranes / ultrasonography*
Fetal Diseases / epidemiology*,  genetics,  ultrasonography
Fetus / anatomy & histology*
Maternal Age
Retrospective Studies
Ultrasonography, Prenatal*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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