| Relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women. | |
| | |
MedLine Citation:
|
PMID: 22153152 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Although fatty acid composition in serum and desaturase activity, which alters serum fatty acid composition, has been associated with C-reactive protein (CRP) concentration in Western populations, no study has been carried out in non-Western populations. We examined the association of serum fatty acids and estimated desaturase activity with CRP concentrations in Japanese men and women. METHODS: Subjects were 489 Japanese municipal employees aged 21-67 years who participated in a survey at the time of a periodic health check-up. Serum high-sensitivity CRP concentrations were measured using the latex agglutination nephelometry method. Fatty acid composition was measured in serum cholesteryl esters and desaturase activities by fatty acid product-to-precursor ratios. Relationships were assessed using multiple regression. RESULTS: Serum CRP concentration was positively associated with palmitic acid (P for trend=0.002) and inversely with alpha-linolenic acid (P for trend=0.01) in men, and positively with dihomo-gamma-linolenic acid (P for trend in men or women=0.01) and inversely with delta-5-desaturase (20:4n-6/20:3n-6) (P for trend in men and women=0.05 and 0.002, respectively) in men and women. CONCLUSIONS: Low-grade inflammation may be associated with a serum fatty acid pattern of high palmitic acid or low alpha-linolenic acid in men, and of high dihomo-gamma-linolenic acid or low delta-5-desaturase in both sexes. |
| | |
Authors:
|
Kalpana Poudel-Tandukar; Masao Sato; Yuko Ejima; Akiko Nanri; Yumi Matsushita; Katsumi Imaizumi; Tetsuya Mizoue |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-19 |
Journal Detail:
|
Title: Atherosclerosis Volume: - ISSN: 1879-1484 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Waseda Institute for Advanced Study (WIAS), Waseda University, 1-6-1 Nishi-waseda, Shinjuku-ku, Tokyo 169-8050, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Temporal profile and prognostic value of Lp-PLA2 mass and activity in the acute stroke setting.
Next Document: Perception and psychological impact of an abnormal Pap smear. Results of a comparative European surv...