| Relationship of serum antioxidant micronutrients and sociodemographic factors to cervical neoplasia: a case-control study. | |
| | |
MedLine Citation:
|
PMID: 19589102 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Although there have been some epidemiological studies on the effects of diet and nutritional status on cervical carcinogenesis, evidence for a protective effect of antioxidant micronutrients against cervical neoplasia is insufficient. The relationship between serum antioxidant micronutrients and sociodemographic factors and the risk of cervical neoplasia was investigated in this multi-center, case-control study. METHODS: The study population included women with histopathological diagnosis of cervical intraepithelial neoplasia (CIN) 1 (n=147), CIN 2/3 (n=177), cervical cancer (n=160), and a control group (n=378). Epidemiological data were collected and the serum concentrations of beta-carotene, lycopene, zeaxanthin plus lutein, retinol, alpha-tocopherol, and gamma-tocopherol were measured using reverse-phase, gradient high-pressure liquid chromatography. RESULTS: Cervical cancer was found to be associated with older age, increased body mass index, and lower socioeconomic status as measured by education level and income. The mean serum concentrations of beta-carotene, lycopene, zeaxanthin plus lutein, retinol, alpha-tocopherol, and gamma-tocopherol of cervical cancer patients were significantly lower than those of control subjects. Odds ratio adjusted for age, smoking status, alcohol consumption, and human papillomavirus infection status revealed a significant gradient of decreasing risk of CIN 1, CIN 2/3, and cervical cancer with increasing serum concentrations of most antioxidant micronutrients. CONCLUSIONS: The results of this study show an inverse association between serum antioxidant micronutrient concentrations and the risk of cervical neoplasia. These results suggest that antioxidant micronutrients play a role in the prevention of cervical carcinogenesis. |
| | |
Authors:
|
Hanbyoul Cho; Mi Kyung Kim; Jae Kwan Lee; Sung Kyong Son; Kwang-Beom Lee; Jong-Min Lee; Jung Pil Lee; Soo Young Hur; Jae-Hoon Kim |
Publication Detail:
|
Type: Journal Article; Multicenter Study |
Journal Detail:
|
Title: Clinical chemistry and laboratory medicine : CCLM / FESCC Volume: 47 ISSN: 1434-6621 ISO Abbreviation: Clin. Chem. Lab. Med. Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-07-31 Completed Date: 2009-10-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9806306 Medline TA: Clin Chem Lab Med Country: Germany |
Other Details:
|
Languages: eng Pagination: 1005-12 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antioxidants / analysis* Case-Control Studies Female Humans Korea / epidemiology Micronutrients / blood* Middle Aged Risk Factors Socioeconomic Factors Uterine Cervical Neoplasms / blood, epidemiology* |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Micronutrients |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heterophile antibodies may falsely increase or decrease thyroglobulin measurement in patients with d...
Next Document: Analysis and interpretation of drug testing results from patients on chronic pain therapy: a clinica...