Document Detail

Relationship of resting hemoglobin concentration to peak oxygen uptake in heart failure patients.
MedLine Citation:
PMID:  20513118     Owner:  NLM     Status:  MEDLINE    
Anemia is frequent in chronic heart failure (HF). To calculate what change in peak oxygen uptake ( VO(2)) should be expected in the event of changes in hemoglobin concentration, we studied the correlation between peak VO(2) and hemoglobin concentration in a large HF population. We carried out retrospective analysis of all cardiopulmonary exercise tests (CPET) performed in our HF Clinic between June 2001 and March 2009 in HF patients who had a resting hemoglobin concentration measurement taken within 7 days of the CPET. We collected 967 CPETs, 704 tests were considered maximal and analyzed. We identified 181 patients (26%) as anemic. Peak VO(2) was lower (P < 0.001) in anemic patients (971 +/- 23 ml/min) compared with nonanemic (1243 +/- 18 ml/min). The slope of the VO(2) vs. hemoglobin ratio was 109 ml/min/g/dl at peak exercise. This correlation remained significant also when several confounding variables were analyzed by multivariate analysis. As an average, each gram of hemoglobin accounts, at peak exercise, for 109 ml/min change in VO(2) which is equivalent to 0.97 ml/min/kg. Therefore, in HF patients anemia treatment should increase VO(2) by 109 ml/min for each g/dl of hemoglobin increase.
Piergiuseppe Agostoni; Elisabetta Salvioni; Chiara Debenedetti; Carlo Vignati; Gaia Cattadori; Mauro Contini; Damiano Magr?; Pietro Palermo; Erica Gondoni; Denise Brusoni; Cesare Fiorentini; Anna Apostolo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  85     ISSN:  1096-8652     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  414-7     Citation Subset:  IM    
Copyright Information:
2010 Wiley-Liss, Inc.
Centro Cardiologico Monzino, IRCCS, Dipartimento di Scienze Cardiovascolari, Universit? di Milano, Milan, Italy.
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MeSH Terms
Anaerobic Threshold
Anemia / blood*,  etiology
Breath Tests
Carbon Dioxide / analysis
Cardiovascular Agents / therapeutic use
Exercise Test
Exercise Tolerance
Heart Failure / blood*,  complications,  drug therapy,  ultrasonography
Hemoglobins / analysis*
Middle Aged
Oxygen Consumption*
Retrospective Studies
Stroke Volume
Reg. No./Substance:
0/Cardiovascular Agents; 0/Hemoglobins; 124-38-9/Carbon Dioxide

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