| Relationship of resting hemoglobin concentration to peak oxygen uptake in heart failure patients. | |
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MedLine Citation:
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PMID: 20513118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anemia is frequent in chronic heart failure (HF). To calculate what change in peak oxygen uptake ( VO(2)) should be expected in the event of changes in hemoglobin concentration, we studied the correlation between peak VO(2) and hemoglobin concentration in a large HF population. We carried out retrospective analysis of all cardiopulmonary exercise tests (CPET) performed in our HF Clinic between June 2001 and March 2009 in HF patients who had a resting hemoglobin concentration measurement taken within 7 days of the CPET. We collected 967 CPETs, 704 tests were considered maximal and analyzed. We identified 181 patients (26%) as anemic. Peak VO(2) was lower (P < 0.001) in anemic patients (971 +/- 23 ml/min) compared with nonanemic (1243 +/- 18 ml/min). The slope of the VO(2) vs. hemoglobin ratio was 109 ml/min/g/dl at peak exercise. This correlation remained significant also when several confounding variables were analyzed by multivariate analysis. As an average, each gram of hemoglobin accounts, at peak exercise, for 109 ml/min change in VO(2) which is equivalent to 0.97 ml/min/kg. Therefore, in HF patients anemia treatment should increase VO(2) by 109 ml/min for each g/dl of hemoglobin increase. |
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Authors:
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Piergiuseppe Agostoni; Elisabetta Salvioni; Chiara Debenedetti; Carlo Vignati; Gaia Cattadori; Mauro Contini; Damiano Magr?; Pietro Palermo; Erica Gondoni; Denise Brusoni; Cesare Fiorentini; Anna Apostolo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of hematology Volume: 85 ISSN: 1096-8652 ISO Abbreviation: Am. J. Hematol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-06-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 414-7 Citation Subset: IM |
Copyright Information:
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2010 Wiley-Liss, Inc. |
Affiliation:
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Centro Cardiologico Monzino, IRCCS, Dipartimento di Scienze Cardiovascolari, Universit? di Milano, Milan, Italy. piergiuseppe.agostoni@unimi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anaerobic Threshold Anemia / blood*, etiology Breath Tests Carbon Dioxide / analysis Cardiovascular Agents / therapeutic use Electrocardiography Exercise Test Exercise Tolerance Female Heart Failure / blood*, complications, drug therapy, ultrasonography Hemoglobins / analysis* Humans Male Middle Aged Oxygen Consumption* Retrospective Studies Stroke Volume |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 0/Hemoglobins; 124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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