Document Detail

Relationship of progesterone/estradiol ratio on day of hCG administration and pregnancy outcomes in high responders undergoing in vitro fertilization.
MedLine Citation:
PMID:  18829018     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the predictive value of a serum P/E(2) ratio measured on the day of hCG administration regarding pregnancy outcomes in high responders undergoing IVF. DESIGN: Retrospective study. SETTING: Teaching hospital. PATIENT(S): Two hundred twenty-three infertile women classified as high responders in IVF-ET cycles. INTERVENTION(S): Eligible infertile women undergoing IVF were assigned to four groups according to serum P levels on the day of hCG administration: group 1, P</=0.9 ng/mL; group 2, 0.9 < P<or=1.4 ng/mL; group 3, 1.4 < P<or=2.0 ng/mL; group 4, P>2.0 ng/mL. The relationship of E(2) level and P/E(2) ratio on the day of hCG administration and pregnancy outcomes was analyzed. MAIN OUTCOME MEASURE(S): Implantation and pregnancy rate. RESULT(S): Patients in group 4 had highest E(2) level and P/E(2) ratio, as well as lowest implantation and pregnancy rates. Using P for grouping, the sensitivity/positive predictive values (%/%) of P/E(2) ratio in the four groups were 15/66, 30/65, 30/60, and 25/41, respectively. CONCLUSION(S): Using the level of a single sex hormone on hCG day to predict pregnancy outcome in high responders undergoing IVF is confounding, whereas using a P/E(2) ratio on hCG day is theoretically reasonable. However, the low sensitivity and positive predictive value make the use of P/E(2) clinically unfeasible.
Fa-Kung Lee; Tsung-Hsuan Lai; Tseng-Kai Lin; Shang-Gwo Horng; Su-Chee Chen
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2008-09-30
Journal Detail:
Title:  Fertility and sterility     Volume:  92     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2009-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1284-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Cathay General Hospital, HsinChu Branch, HsinChu, Taiwan.
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MeSH Terms
Chorionic Gonadotropin / administration & dosage,  therapeutic use*
Estradiol / analysis,  blood*
Fertility Agents, Female / administration & dosage,  therapeutic use
Fertilization in Vitro / methods*
Follicle Stimulating Hormone / blood
Infertility, Female / blood,  diagnosis,  therapy
Luteinizing Hormone / blood
Ovulation Induction / methods*
Predictive Value of Tests
Pregnancy Outcome*
Progesterone / analysis,  blood*
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Fertility Agents, Female; 50-28-2/Estradiol; 57-83-0/Progesterone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

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