| Relationship of pulmonary vein flow to left ventricular short-axis epicardial displacement in diastole: model-based prediction with in vivo validation. | |
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MedLine Citation:
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PMID: 16603684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies in healthy humans have established that the (approximately 850 ml) volume enclosed by the pericardial sac is nearly constant over the cardiac cycle, exhibiting a transient approximately 5% decrease (approximately 40 ml) from end diastole to end systole. This volume decrease manifests as a "crescent" at the ventricular free wall level when short-axis MRI images of the epicardial surface acquired at end systole and end diastole are superimposed. On the basis of the (near) constant-volume property of the four-chambered heart, the volume decrease ("crescent effect") must be restored during subsequent early diastolic filling via the left atrial conduit volume. Therefore, volume conservation-based modeling predicts that pulmonary venous (PV) Doppler D-wave volume must be causally related to the radial displacement of the epicardium (Delta) (i.e., magnitude of "crescent effect" in the radial direction). We measured Delta from M-mode echocardiographic images and measured D-wave velocity-time integral (VTI) from Doppler PV flow of the right superior PV in 11 subjects with catheterization-determined normal physiology. In accordance with model prediction, high correlation was observed between Delta and D-wave VTI (r=0.86) and early D-wave VTI measured to peak D-wave velocity (r=0.84). Furthermore, selected subjects with various pathological conditions had values of Delta that differed significantly. These observations demonstrate the volume conservation-based causal relationship between radial pericardial displacement of the left ventricle and the PV D-wave-generated filling volume in healthy subjects as well as the potential role of the M-mode echo-derived radial epicardial displacement index Delta as a regional (radial) parameter of diastolic function. |
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Authors:
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Matt M Riordan; Sándor J Kovács |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Studies Date: 2006-04-07 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 291 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-10 Completed Date: 2006-09-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1210-5 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Cardiovascular Biophysics Laboratory, Washington University School of Medicine, St. Louis, MO 63110, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Circulation
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physiology Diastole / physiology* Echocardiography Echocardiography, Doppler Heart Ventricles / anatomy & histology, pathology Humans Hypertrophy, Left Ventricular / pathology, physiopathology Magnetic Resonance Imaging Middle Aged Mitral Valve Insufficiency / pathology, physiopathology Models, Cardiovascular Models, Theoretical* Pericardium / anatomy & histology, pathology, physiology* Pulmonary Veins / anatomy & histology, pathology, physiology* Ventricular Function* |
| Grant Support | |
ID/Acronym/Agency:
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HL-04023/HL/NHLBI NIH HHS; HL-54179/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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