Document Detail


Relationship of pregnancy to human papillomavirus among human immunodeficiency virus-infected women.
MedLine Citation:
PMID:  17012459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Because parity is a reported risk factor for cervical cancer, we sought to estimate the effects of pregnancy on the prevalence, incident detection, and copy number of human papillomavirus (HPV) among human immunodeficiency virus (HIV)-infected women, patients at high risk for cervical cancer. METHODS: Human immunodeficiency virus-infected women who had a pregnancy in the Women's Interagency HIV Study (n = 178) and the Women and Infants Transmission Study (n = 450) underwent serial type-specific HPV DNA testing using MY09/MY11 polymerase chain reaction. During pregnancy and during the prepregnancy and postpregnancy periods, we assessed HPV prevalence, incident detection, and HPV copy number (estimated using hybridization signal strength) of both oncogenic and nononcogenic HPV. All binary-regression analyses incorporated generalized estimating equations to address the repeated observations of the same women over time, and were further adjusted for parity, gestational age, smoking, antiretroviral use, number of lifetime sexual partners, and oral contraceptive use. RESULTS: The prevalence and copy number of oncogenic and nononcogenic HPV did not significantly differ between pregnancy and either the prepregnancy or postpregnancy periods. Incident HPV detection was significantly lower for both oncogenic and nononcogenic HPV during pregnancy compared with the postpregnancy period (relative risk 0.534, 95% confidence interval 0.390-0.732, P < .001 and relative risk 0.577, 95% confidence interval 0.428-0.779, P < .001, respectively), but not compared with the prepregnancy period CONCLUSION: Among HIV-infected women, the incident detection of HPV is lower during pregnancy compared with postpregnancy, while prevalence and copy number do no differ between pregnancy and either prepregnancy or postpregnancy. LEVEL OF EVIDENCE: II-3.
Authors:
Howard Minkoff; XianLin Shen; Lin Shen Xian; D Heather Watts; Robert Leighty; Ron Hershow; Joel Palefsky; Ruth Tuomala; Natalie Neu; Carmen D Zorrilla; Mary Paul; Howard Strickler
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  108     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-02     Completed Date:  2006-10-27     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  953-60     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Maimonides Medical Center and SUNY Downstate, Brooklyn, New York, USA. Hminkoff@maimonidesmed.org
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MeSH Terms
Descriptor/Qualifier:
AIDS-Related Opportunistic Infections / epidemiology*
Adult
DNA, Viral / analysis
Female
HIV Infections / complications*
Humans
Papillomaviridae / genetics,  isolation & purification*
Papillomavirus Infections / epidemiology*
Pregnancy
Pregnancy Complications, Infectious / epidemiology*
Prevalence
Regression Analysis
Smoking / adverse effects
Grant Support
ID/Acronym/Agency:
CA85178-06/CA/NCI NIH HHS; M01-RR-00071/RR/NCRR NIH HHS; M01-RR-00079/RR/NCRR NIH HHS; M01-RR-00083/RR/NCRR NIH HHS; RR000188/RR/NCRR NIH HHS; RR000645/RR/NCRR NIH HHS; U01-AI-31834/AI/NIAID NIH HHS; U01-AI-34989/AI/NIAID NIH HHS; U01-AI-34993/AI/NIAID NIH HHS; U01-AI-34994/AI/NIAID NIH HHS; U01-AI-35004/AI/NIAID NIH HHS; U01-AI-42590/AI/NIAID NIH HHS; U01-HD-32632/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Viral
Comments/Corrections
Erratum In:
Obstet Gynecol. 2007 Jul;110(1):191
Note: Xian, Lin Shen [corrected to Shen, XianLin]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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