| Relationship of pregnancy-associated alpha2-glycoprotein (alpha2-PAG) to peripheral blood leucocytes. | |
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MedLine Citation:
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PMID: 81516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The high molecular weight plasma glycoprotein pregnancy-associated alpha2-glycoprotein (alpha2-PAG) can be demonstrated on the surface of blood leucocytes and is synthesized by oestrogen-stimulated cells in culture. By the use of an indirect immunofluorescence technique, pretreatment of leucocytes with anti-alpha2-PAG IgG revealed alpha2-PAG on C3 rosette-forming cells and monocytes but not on E rosettes. Lymphocytes treated with anti-alpha2-PAG showed markedly diminished ability to form Fc rosettes. A percentage ranging from 15% to 20% of leucocytes from normal adults of both sexes, pregnant and oestrogen-treated females were positive for alpha2-PAG but no obvious correlatin was observed between the incidence of alpha2-PAG bearing cells and plasma levels of the protein. |
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Authors:
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C H Horne; A W Thomson; C M Towler; F K MacMillan; L M Gibb |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of immunology Volume: 8 ISSN: 0300-9475 ISO Abbreviation: Scand. J. Immunol. Publication Date: 1978 |
Date Detail:
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Created Date: 1978-12-27 Completed Date: 1978-12-27 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0323767 Medline TA: Scand J Immunol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 75-80 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cells, Cultured Estrogens / pharmacology Female Fluorescent Antibody Technique Humans Immunoelectrophoresis Immunoglobulin Fc Fragments Leukocytes / immunology, metabolism* Male Monocytes / immunology Pregnancy* Rosette Formation Staining and Labeling alpha-Macroglobulins* / analysis, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Immunoglobulin Fc Fragments; 0/alpha-Macroglobulins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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