Document Detail


Relationship of the predatory attack experience to neural plasticity, pCREB expression and neuroendocrine response.
MedLine Citation:
PMID:  16115684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aggression takes at least two, an attacker and a target. This paper will address the lasting consequences of being a target of aggression. We review the lasting impact of predatory attack on brain and behavior in rodents. A single brief unprotected exposure of a rat to a cat lastingly alters affective responses of rats in a variety of contexts. Alterations of these behaviors resembles both generalized anxiety comorbid with post traumatic stress disorder (PTSD), and the hyper arousal expressed in enhanced startle in PTSD. Examination of neural transmission and neural plasticity in limbic circuits implicates changes in transmission in two connecting pathways in many but not all of the behavioral changes. Quantification of the predator encounter reveals that both the behavior of the predator and the reaction of the rat to attack are highly predictive of the effects of predatory attack on molecular biological (pCREB expression) and electrophysiological measures of limbic neuroplastic change. Moreover, a case will be made that the pattern of change of corticosteroid level over three hours after the predator encounter, in interaction with the predatory experience, plays an important part in initiation of lasting changes in brain and behavior.
Authors:
Robert E Adamec; Jacqueline Blundell; Paul Burton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-22
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  30     ISSN:  0149-7634     ISO Abbreviation:  Neurosci Biobehav Rev     Publication Date:  2006  
Date Detail:
Created Date:  2006-02-17     Completed Date:  2006-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  356-75     Citation Subset:  IM    
Affiliation:
Department of Psychology, Memorial University, 232 Elizabeth Ave., St. John's, Nl, Canada, A1B 3X9. radamec@mun.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Cerebral Cortex / physiology
Corticosterone / blood
Cyclic AMP Response Element-Binding Protein / biosynthesis,  genetics,  physiology*
Darkness
Electrodes, Implanted
Electrophysiology
Functional Laterality / physiology
Handling (Psychology)
Hydrogen-Ion Concentration
Image Processing, Computer-Assisted
Immunohistochemistry
Interpersonal Relations
Light
Male
Neuronal Plasticity / physiology*
Neurosecretory Systems / physiology*
Predatory Behavior / physiology*
Rats
Rats, Long-Evans
Chemical
Reg. No./Substance:
0/Cyclic AMP Response Element-Binding Protein; 50-22-6/Corticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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