| Relationship of plasma brain-type natriuretic peptide levels to left ventricular longitudinal function in patients with congestive heart failure assessed by strain Doppler imaging. | |
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MedLine Citation:
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PMID: 18068244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Plasma brain-type natriuretic peptide (BNP) levels have been used to diagnose congestive heart failure (CHF), but significant heterogeneity in BNP levels is not explained by standard echocardiographic indexes of cardiac function. Recent data indicate that longitudinal left ventricular (LV) dysfunction exists in the presence of normal standard echocardiographic indexes and BNP was predicted well by LV longitudinal systolic velocity. We examined whether longitudinal LV function assessed by strain or strain rate (SR) tissue Doppler imaging could be determinants of plasma BNP levels in patients with CHF. METHODS: We examined 137 consecutive patients with suspected CHF. Standard echocardiography and Doppler flow records were obtained. Strain, and SR at the basal and mid parts of the ventricle were investigated in 2 apical views. Tissue velocities of mitral annulus were also obtained. Plasma BNP levels were measured on the day of echocardiography. RESULTS: Multivariate analysis showed the mean longitudinal LV strain (r=0.75, P<0.0001) to be an independent powerful predictor of plasma log BNP levels. Subgroup analysis (ejection fraction <50%, n=30; ejection fraction >50%, n=107) also showed that the mean longitudinal LV strain (r=0.89, P<0.0001; r=0.68, P<0.0001, respectively) was only an independent predictor of log BNP levels. CONCLUSION: Longitudinal LV strain is closely related to log BNP levels in patients with CHF, both in patients with systolic and diastolic heart failure. |
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Authors:
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Ayako Yoneyama; Jun Koyama; Takeshi Tomita; Setsuo Kumazaki; Hiroshi Tsutsui; Noboru Watanabe; Osamu Kinoshita; Uichi Ikeda |
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Publication Detail:
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Type: Journal Article Date: 2007-12-18 |
Journal Detail:
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Title: International journal of cardiology Volume: 130 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-22 Completed Date: 2009-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 56-63 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Echocardiography, Doppler Female Heart Failure / blood*, physiopathology, ultrasonography Humans Male Middle Aged Natriuretic Peptide, Brain / blood* Ventricular Dysfunction, Left / blood*, physiopathology, ultrasonography Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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