Document Detail


Relationship of phospho-pRb (Ser-807/811) level to exposure to tobacco smoke in primary non-small cell lung cancer.
MedLine Citation:
PMID:  18938028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was aimed at understanding the effect of smoking on pRb phosphorylation and the clinicopathological significance of phospho-pRb in non-small cell lung cancers (NSCLCs). Phospho-pRb (Ser-807/811) expression was not detected in 149 (39%) of 382 patients, and the mean phospho-pRb (Ser-807/811) level was 5.7%. Squamous cell carcinoma had higher phospho-pRb (Ser-807/811) levels than adenocarcinoma (7.1%+/-10.4% versus 4.7%+/-7.9%; P=0.003). The association between phospho-pRb (Ser-807/811) levels and exposure to tobacco smoke was different according to the statuses of cyclin D1 expression and p16 methylation, suggesting that their statuses might play a role as an effect modifier in the relationship between phospho-pRb (Ser-807/811) levels and exposure to tobacco smoke. In stratified multivariate analysis, phospho-pRb (Ser-807/811) levels were not associated with exposure to tobacco smoke in 38 patients with p16 hypermethylation and cyclin D1 expression >5%, after adjusting for confounding factors. However, in the remaining 344 patients, the mean phospho-pRb (Ser-807/811) levels in patients who had smoked >40 pack years increased by 4.65% (P<0.0001) on average than those who had never smoked. No association was found between the phospho-pRb (Ser-807/811) levels and overall survival. In conclusion, the present study suggests that exposure to tobacco smoke is associated with phosphorylation of pRb in NSCLC patients and its relationship depends on the p16 methylation status and cyclin D1 expression levels.
Authors:
Eunkyung Ko; Yujin Kim; Bo Bin Lee; Joungho Han; Sang Yong Song; Young Mog Shim; Joobae Park; Duk-Hwan Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-19
Journal Detail:
Title:  Cancer letters     Volume:  274     ISSN:  1872-7980     ISO Abbreviation:  Cancer Lett.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  225-32     Citation Subset:  IM    
Affiliation:
Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 440-746, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Non-Small-Cell Lung / etiology,  metabolism*,  pathology
DNA Methylation
Female
Humans
Immunohistochemistry
Lung Neoplasms / etiology,  metabolism*,  pathology
Male
Middle Aged
Multivariate Analysis
Phosphorylation
Polymerase Chain Reaction
Retinoblastoma Protein / chemistry,  metabolism*
Serine / metabolism*
Smoke*
Tobacco*
Chemical
Reg. No./Substance:
0/Retinoblastoma Protein; 0/Smoke; 56-45-1/Serine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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