Document Detail

Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression.
MedLine Citation:
PMID:  21903666     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Structural brain abnormalities are associated with late-life major depression, with numerous studies reporting increased white matter hyperintensities (WMH) and reduced cortical/subcortical grey matter volumes. There is strong evidence linking vascular disease to WMH, but limited evidence on its association with subcortical volumes.
AIMS: To investigate the relationship of orthostatic blood pressure changes to WMH and subcortical grey matter volumes in late-life depression.
METHOD: Thirty-eight people with depression and a similarly aged comparison group (n = 30) underwent fluid attenuated inversion recovery (FLAIR) and T(1)-weighted magnetic resonance imaging as well as systematic orthostatic blood pressure assessments. Volumetric estimates of WMH and subcortical grey matter were obtained for each participant and the relationship to blood pressure drop on active stand was examined.
RESULTS: An association between orthostatic systolic blood pressure drop and WMH volumes in temporal and parietal regions was found in the depression group (age-corrected partial correlation r' = 0.31-0.35, P<0.05). Subcortical volumes were not related to blood pressure changes or WMH volumes in either group.
CONCLUSIONS: We found evidence for an association between the degree of orthostatic systolic blood pressure drop and WMH volume in the depression group. Since blood pressure drops lead to WMH in animals our findings suggest systolic blood pressure drops may be a factor contributing to these lesions in late-life depression.
Sean J Colloby; Akshya Vasudev; John T O'Brien; Michael J Firbank; Steve W Parry; Alan J Thomas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-09-08
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  199     ISSN:  1472-1465     ISO Abbreviation:  Br J Psychiatry     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-02     Completed Date:  2011-12-27     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  404-10     Citation Subset:  IM    
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MeSH Terms
Age of Onset
Antihypertensive Agents / therapeutic use
Blood Pressure / physiology
Blood Pressure Determination / methods
Case-Control Studies
Depressive Disorder, Major / epidemiology,  pathology*,  physiopathology
Hypotension, Orthostatic / epidemiology,  pathology*,  physiopathology
Image Processing, Computer-Assisted
Magnetic Resonance Imaging / methods
Middle Aged
Neuropsychological Tests
Parietal Lobe / blood supply,  pathology*
Psychiatric Status Rating Scales
Severity of Illness Index
Temporal Lobe / blood supply,  pathology*
Grant Support
G0400074//Medical Research Council; G0502157//Medical Research Council; G0900652//Medical Research Council
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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