Document Detail


Relationship of nonspecific antiarrhythmic and negative inotropic activity with physicochemical parameters of propranolol analogues.
MedLine Citation:
PMID:  423187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In an attempt to separate the nonspecific antiarrhythmic activity of propranolol from its negative inotropic effects, analogues containing hydrophilic and lipophilic substituents on the nitrogen and on the naphthyl ring were prepared and tested in an isolated tissue preparation. Though it had been predicted that analogues containing a very hydrophilic group on the nitrogen would have the highest antiarrhythmic/negative inotropic effect ratio, it was found that both effects increased identically when the lipophilicity of either the nitrogen or ring substituent was increased.
Authors:
D O Rauls; J K Baker
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  22     ISSN:  0022-2623     ISO Abbreviation:  J. Med. Chem.     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-05-23     Completed Date:  1979-05-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  81-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Arrhythmia Agents*
Chemistry, Physical
Lipids
Myocardial Contraction / drug effects*
Physicochemical Phenomena
Propranolol / analogs & derivatives*,  chemical synthesis,  pharmacology
Rabbits
Solubility
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Lipids; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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