| Relationship of nonspecific antiarrhythmic and negative inotropic activity with physicochemical parameters of propranolol analogues. | |
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MedLine Citation:
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PMID: 423187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an attempt to separate the nonspecific antiarrhythmic activity of propranolol from its negative inotropic effects, analogues containing hydrophilic and lipophilic substituents on the nitrogen and on the naphthyl ring were prepared and tested in an isolated tissue preparation. Though it had been predicted that analogues containing a very hydrophilic group on the nitrogen would have the highest antiarrhythmic/negative inotropic effect ratio, it was found that both effects increased identically when the lipophilicity of either the nitrogen or ring substituent was increased. |
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Authors:
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D O Rauls; J K Baker |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: 22 ISSN: 0022-2623 ISO Abbreviation: J. Med. Chem. Publication Date: 1979 Jan |
Date Detail:
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Created Date: 1979-05-23 Completed Date: 1979-05-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 81-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Arrhythmia Agents* Chemistry, Physical Lipids Myocardial Contraction / drug effects* Physicochemical Phenomena Propranolol / analogs & derivatives*, chemical synthesis, pharmacology Rabbits Solubility Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Lipids; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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