Document Detail


Relationship of nidal vessel radius and wall thickness to brain arteriovenous malformation hemorrhage.
MedLine Citation:
PMID:  12117322     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cerebral (brain) arteriovenous malformations (BAVMs) are a tangle of disorganized vessels that are a rare cause of hemorrhagic stroke in the general population. Although clinical presentation of hemorrhage may be related to the structure of BAVM vessels, there has been no systematic quantitative analysis of BAVM vessel morphology. Histological sections of excised BAVM lesions were prepared from patients who presented with hemorrhage (n = 14) and from patients with no history of hemorrhage (n = 22). Mean values of radius and wall thickness in each section were determined. BAVM radii were 422+/-136 microm (mean +/- SD), minimum wall thickness (thinnest portion of the wall) was 54+/-14 microm; and the minimum thickness/radius ratio was 0.23+/-0.07. Greater vessel wall thickness was associated with hemorrhagic presentation (OR= 1.1; p = 0.046) after adjusting for feeding artery pressure. Because BAVM vessels from patients presenting with hemorrhage had thicker vessel walls, the search for structural properties predisposing BAVM rupture should be expanded beyond the morphological properties analyzed here.
Authors:
Christopher M Quick; David J James; Kelvin Ning; Shailandra Joshi; Alexander X Halim; Tomoki Hashimoto; William L Young
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurological research     Volume:  24     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-15     Completed Date:  2003-01-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  495-500     Citation Subset:  IM    
Affiliation:
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco 94110, USA. quickc@anesthesia.ucsf.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Anthropometry
Blood Vessels / pathology*,  physiopathology
Cerebrovascular Circulation / physiology
Female
Humans
Intracranial Arteriovenous Malformations / complications*,  pathology*,  physiopathology
Intracranial Hemorrhages / etiology*,  pathology*,  physiopathology
Male
Middle Aged
Grant Support
ID/Acronym/Agency:
5T32GM08440/GM/NIGMS NIH HHS; K24 NS 02091/NS/NINDS NIH HHS; R01 NS 37921/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Advanced atherosclerosis of the aortic arch is uncommon in ischemic stroke: an autopsy study.
Next Document:  Klippel-Feil syndrome associated with posterior fossa dermoid cyst. Case report.