Document Detail


Relationship of mouse body weight and food consumption/wastage to cage shelf level.
MedLine Citation:
PMID:  6664066     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relationships between the shelf level at which mice were housed and body weight and food consumption/wastage were examined by analyzing data obtained from the first 9 months of a carcinogenic dose-response study carried out in 24,192 female BALB/c mice using 2-acetylaminofluorene (2-AAF) as the carcinogen. Each cage, containing four mice, was maintained on a rack at a given shelf level throughout the course of the experiment to allow analysis of data by shelf level. The amount of food removed from each feeder and the body weight of each mouse was measured weekly. Average body weight gain during the first 12 weeks was lowest on the top shelf, highest on the next two shelves, and progressively lower as the shelf approached the lowest level on the rack. Body weights attained by week 36 of the experiment generally reflected this same pattern. Weekly food consumption/wastage, as measured by disappearance of food from the feeder, generally showed the converse shelf-level pattern as that shown by body weight gain. Removal of food from feeders was greatest on the top shelf, lowest on the next shelf, and progressively increased with each succeedingly lower shelf. Although it is not clear whether the food removal pattern was related more to food consumption or food wastage, the observation was reproducible.
Authors:
D L Greenman; P Bryant; R L Kodell; W Sheldon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Laboratory animal science     Volume:  33     ISSN:  0023-6764     ISO Abbreviation:  Lab. Anim. Sci.     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-03-12     Completed Date:  1984-03-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1266503     Medline TA:  Lab Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  555-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
2-Acetylaminofluorene
Animals
Body Weight*
Feeding Behavior*
Female
Housing, Animal*
Mice
Mice, Inbred BALB C / physiology*
Neoplasms, Experimental / chemically induced
Chemical
Reg. No./Substance:
53-96-3/2-Acetylaminofluorene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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