Document Detail

Relationship of metabolic syndrome with pulse pressure in patients with essential hypertension.
MedLine Citation:
PMID:  17261467     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pulse pressure is largely dependent on arterial stiffness. Recent studies have documented reduced large artery compliance in nondiabetic subjects with metabolic syndrome (MS). The aim of our study was to analyze, in a group of patients with essential hypertension and without diabetes mellitus, the influence of MS on clinic and 24-h pulse pressures. METHODS: A total of 528 hypertensive subjects, aged 18 to 72 years, who were free of cardiovascular and renal diseases were enrolled. Of the subjects, 41% had MS. In all subjects routine blood chemistry, echocardiographic examination, and 24-h ambulatory blood pressure monitoring were performed. RESULTS: When compared with subjects without MS, hypertensive patients with MS exhibited more elevated clinic pulse pressures (66 +/- 16 v .58 +/- 14 mm Hg; P < .00001) and 24-h (51 +/- 9 v .48 +/- 7 mm Hg; P = .00001). These results held even after correction for age, sex, stroke volume, mean pressures, and total cholesterol. The regression line relating PP with age was steeper in patients with MS than in those without MS. Multivariate regression models confirmed that the relationships of MS with clinic (beta = 0.12; P = .003) and 24-h PP (beta = 0.11; P = .01) were independent from several confounding factors. CONCLUSIONS: The elevated levels of clinic and 24-h PP observed in hypertensive patients with MS may reflect increased large arteries stiffness and may therefore contribute to explain the enhanced cardiovascular risk associated with MS.
Giuseppe Mulè; Emilio Nardi; Santina Cottone; Paola Cusimano; Francesca Incalcaterra; Alessandro Palermo; Maria Ester Giandalia; Giovanni Mezzatesta; Giuseppe Andronico; Giovanni Cerasola
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  20     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-30     Completed Date:  2007-05-07     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  197-203     Citation Subset:  IM    
Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche, Cattedra di Medicina Interna e Unità Operativa di Medicina Interna, Nefrologia ed Ipertensione, Università di Palermo, Palermo, Italy.
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MeSH Terms
Arteries / physiopathology*
Blood Pressure*
Blood Pressure Determination
Heart Rate
Hypertension / complications,  epidemiology*,  physiopathology*
Metabolic Syndrome X / complications,  physiopathology*
Middle Aged
Pulsatile Flow
Risk Factors
Comment In:
Am J Hypertens. 2007 Feb;20(2):204-5   [PMID:  17261468 ]
Am J Hypertens. 2007 Sep;20(9):1024-5; author reply 1025-6   [PMID:  17765147 ]

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