Document Detail

Relationship of maternal protein turnover and lean body mass during pregnancy and birth length.
MedLine Citation:
PMID:  11410116     Owner:  NLM     Status:  MEDLINE    
Epidemiological evidence shows that small size at birth is associated with an increased risk of developing cardiovascular and metabolic disease in adult life. We have examined the relationships between size at birth and maternal body composition and protein turnover in normal pregnant women. A group of 27 multiparous Caucasian women with singleton pregnancies were studied at around 18 and 28 weeks' gestation. Body composition was determined by anthropometry, and whole-body protein turnover was estimated by using a single oral dose of [(15)N]glycine and the end-product method. The baby's weight and length were measured within 48 h of birth. Mothers with a greater lean body mass had higher rates of protein turnover at 18 weeks' gestation. This association was largely accounted for by differences in the mother's visceral, rather than muscle, mass. Mothers who had higher protein turnover at 18 weeks' gestation had babies that were longer at birth. After adjustment for the duration of gestation and the baby's sex, 26% of the variation in length at birth was accounted for by maternal protein synthesis at 18 weeks' gestation. Maternal protein intake was not associated with the baby's birth length. Thus the mother's ability to nourish her fetus is influenced by her body composition and her rate of protein turnover. Dietary intake does not adequately characterize this ability.
S L Duggleby; A A Jackson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  101     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-06-18     Completed Date:  2001-08-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  65-72     Citation Subset:  IM    
Medical Research Council Environmental Epidemiology Unit, Southampton General Hospital, Southampton SO16 6YD, U.K.
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MeSH Terms
Birth Weight / physiology*
Body Composition / physiology*
Body Weight / physiology*
Diet Records
Dietary Proteins / administration & dosage,  metabolism*
Gestational Age
Infant, Newborn
Linear Models
Nitrogen Isotopes / metabolism
Pregnancy / metabolism*
Pregnancy Trimester, Second
Skinfold Thickness
Reg. No./Substance:
0/Dietary Proteins; 0/Nitrogen Isotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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