| Relationship of insulin resistance in chronic haemodialysis patients with inflammatory indicators, malnutrition, echocardiographic parameters and 24 hour ambulatory blood pressure monitoring. | |
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MedLine Citation:
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PMID: 20377496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The relationship between malnutrition, echocardiographic parameters, 24 h ambulatory blood pressure (ABP) parameters and decreased insulin sensitivity index (ISI-S) in chronic haemodialysis patients was investigated. MATERIAL AND METHODS: ISI-S and inflammatory indicators were measured. The nutritional state was assessed by malnutrition score. Echocardiography and 24 h ABP were performed 1 day before the second haemodialysis session of the week. RESULTS: ISI-S was inversely correlated with the night-time mean blood pressure (BP)/day-time mean BP ratio (p = 0.021) and malnutrition score (p < 0.01). High-sensitivity C-reactive protein, night-time mean BP/day-time mean BP and vena cava collapse index were independent risk factors affecting ISI-S (p < 0.001; beta = 0.412, p = 0.025; beta = -0.204, p < 0.001; beta = -0.465). CONCLUSIONS: The decrease in ISI-S along with the hypervolaemia suggests that volume overload is a contributory factor in the pathogenesis of insulin resistance in patients with chronic renal failure. This study indicates that, in addition to the traditional cardiovascular risk factors in these patients, insulin resistance can be regarded as a risk factor, but not an independent one, mainly a reflection of the underlying culprit, hypervolaemia. |
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Authors:
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Seyhun Kurşat; Hulya Bahadir Colak; Aysun Toraman; Hikmet Tekçe; Cevval Ulman; Ozgur Bayturan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of urology and nephrology Volume: 44 ISSN: 1651-2065 ISO Abbreviation: Scand. J. Urol. Nephrol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-12 Completed Date: 2010-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0114501 Medline TA: Scand J Urol Nephrol Country: England |
Other Details:
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Languages: eng Pagination: 257-64 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Celal Bayar University Medical Faculty, Manisa, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Pressure / physiology* Blood Pressure Monitoring, Ambulatory Circadian Rhythm / physiology Cross-Sectional Studies Echocardiography Female Humans Inflammation / epidemiology, physiopathology* Insulin Resistance / physiology* Kidney Diseases / physiopathology*, therapy Male Malnutrition / epidemiology, physiopathology* Middle Aged Renal Dialysis* Risk Factors Sensitivity and Specificity Vena Cava, Inferior / physiopathology, ultrasonography* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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