| Relationship of initial glucose level and all-cause death in patients with ischaemic stroke: the roles of diabetes mellitus and glycated hemoglobin level. | |
| | |
MedLine Citation:
|
PMID: 22289016 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background and purpose: Previous studies demonstrated that post-stroke hyperglycemia was associated with poor outcome in non-diabetic patients. However, evidence was inconclusive amongst patients with diabetes. The aim of this study was to evaluate the relationship between initial glucose levels and mortality amongst patients with acute ischaemic stroke, and further, to assess whether the association varied by diabetes mellitus and glycated hemoglobin (HbA(1c) ) levels. Methods: Data were collected from the medical records of 1277 first-ever stroke patients admitted to the emergency room between January 1, 2008 and June 30, 2009. Cox regression analysis was performed to assess the relationship between initial glucose level and mortality. Results: Compared with the lowest quartile of initial glucose level, a significant association with all-cause death [hazard ratio (HR), 2.18; 95% CI, 1.36-3.48] and cardiovascular death (HR, 1.91; 95% CI, 1.01-3.61) was seen in the highest quartile. In non-diabetic subgroup, those patients within the highest quartile of initial glucose level had a 3.29-fold relative risks (RR) [95% confidence interval (CI), 1.62-6.68] for all-cause and a 2.54-fold RR (95% CI, 1.43-8.77) for cardiovascular death compared with those within the lowest quartile. However, the association between initial glucose levels and the risk of death was not significant amongst those with diabetes (P for interaction = 0.01). In addition, the risk amongst patients with diabetes varied by the HbA(1c) levels. Conclusions: A significant association was confirmed between initial glucose level and mortality in non-diabetic ischaemic stroke patients. The possible relationship between initial glucose level, HbA(1c) level, and mortality amongst ischaemic stroke patients with diabetes warrants further research. |
| | |
Authors:
|
G-C Hu; S-F Hsieh; Y-M Chen; H-H Hsu; Y-N Hu; K-L Chien |
Related Documents
:
|
17728716 - Glucose sensing by pomc neurons regulates glucose homeostasis and is impaired in obesity. 16353346 - Insulin levels, physical activity, and urinary catecholamine excretion of obese and non... 18269176 - Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes. 6046046 - The obese person as an adolescent. 18606936 - Health-related quality of life of children and adolescents with type 1 or type 2 diabet... 10869516 - The temporal and spatial expressions of neuropeptide y induced by seizure in the hippoc... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-31 |
Journal Detail:
|
Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: - ISSN: 1468-1331 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 The Author(s). European Journal of Neurology © 2012 EFNS. |
Affiliation:
|
Department of Rehabilitation Medicine, Mackay Memorial Hospital, Taipei Department of Neurology, Mackay Memorial Hospital, Taipei Department of Medical Education, Mackay Memorial Hospital, Taipei Institute of Economics and Social Studies, National United University, Miaoli Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Theoretical insights into interprofessional education: AMEE Guide No. 62.
Next Document: The operative safety and oncological outcomes of laparoscopic nephrectomy for T3 renal cell cancer.