Document Detail

Relationship of home blood pressure with target-organ damage in children and adolescents.
MedLine Citation:
PMID:  21326307     Owner:  NLM     Status:  Publisher    
The objective of this study was to compare home blood pressure (HBP) vs. ambulatory (ABP) and clinic (CBP) measurements in terms of their association with target-organ damage in children and adolescents. A total of 81 children and adolescents (mean age 13±3 years, 53 boys) referred for elevated CBP had measurements of CBP (1 visit), HBP (6 days) and ABP (24-h). Seventy-six participants were also assessed with carotid-femoral pulse wave velocity (PWV) and 54 with echocardiography. Average CBP was 122.1±15.1/71±12.9 mm Hg (systolic/diastolic), HBP 121.3±11.5/69.4±6.6 mm Hg and 24-h ABP 118.9±12/66.6±6.1 mm Hg. Left ventricular mass (LVM) was correlated with systolic blood pressure (BP) (coefficient r=0.55/0.54/0.45 for 24-h/daytime/nighttime ABP, 0.53 for HBP and 0.41 for CBP; all P<0.01). No significant correlations were found for diastolic BP. PWV was also significantly correlated with systolic BP (r=0.52/0.50/0.48 for 24-h/daytime/nighttime ABP, 0.50 for HBP and 0.47 for CBP; all P<0.01). Only diastolic ABP and HBP were significantly correlated with PWV (r=0.30 and 0.28, respectively, P<0.05). In multivariate stepwise regression analysis (with age, gender, body mass index [BMI], clinic, home and 24-h ambulatory systolic/diastolic BP and pulse pressure, clinic, home and 24-h heart rate as independent variables), PWV was best predicted by systolic HBP (R(2)=0.22, beta±s.e. =0.06±0.01), whereas LVM was determined (R(2)=0.67) by 24-h pulse pressure (beta=1.21±0.41), age (beta=2.93±1.32), 24-h heart rate (beta=-1.27±0.41) and BMI (beta=1.78±0.70). These data suggest that, in children and adolescents, ABP as well as HBP measurements appear to be superior to the conventional CBP measurements in predicting the presence of subclinical end-organ damage.Hypertension Research advance online publication, 17 February 2011; doi:10.1038/hr.2011.10.
George S Stergiou; Periklis P Giovas; Anastasios Kollias; Vayia C Rarra; John Papagiannis; Dimitris Georgakopoulos; Andriani Vazeou
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-17
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  -     ISSN:  1348-4214     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Hypertension Center, Third University Department of Medicine, Sotiria Hospital, Athens, Greece.
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