| Relationship of heavy drinking, lipoprotein (a) and lipid profile to infrarenal aortic diameter. | |
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MedLine Citation:
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PMID: 19808717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to examine the association of alcohol drinking and lipid profile with infrarenal aortic dimension. The diameter of the infrarenal aorta was measured using ultrasound in 395 individuals (mean 66.6 +/- 10.3 years) with atherosclerotic diseases or risk factors. The associations between heavy drinking, serum lipoprotein (a) levels, lipid profile and infrarenal aorta diameters were examined. Heavy drinking and lipoprotein (a) were positively related with infrarenal aortic dimension, while low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C), LDL-C and total cholesterol (TC)/HDL-C were negatively associated with infrarenal aortic diameter (p < 0.05). In addition, there were negative associations of LDL-C/HDL-C, TC/HDL-C and positive associations of HDL-C and apolipoprotein AI (Apo AI) with heavy drinking (p < 0.05). In conclusion, there was a positive association between infrarenal aortic diameters and heavy drinking, as well as lipoprotein (a) levels. Furthermore, the novel and unexpected inverse association between LDL-C/HDL-C, LDL-C, TC/HDL-C and abdominal aortic diameter may suggest a possible role for anti-atherogenic lipid profile (characterized by a higher level of HDL-C and lower level of LDL-C) in aortic dilatation processes, which need to be clarified by further studies. |
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Authors:
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Jian-an Wang; Xiao-feng Chen; Wei-fang Yu; Han Chen; Xian-fang Lin; Mei-jiang Xiang; Cong-feng Fang; Yu-xi Du; Bin Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Vascular medicine (London, England) Volume: 14 ISSN: 1358-863X ISO Abbreviation: Vasc Med Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-07 Completed Date: 2009-12-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610930 Medline TA: Vasc Med Country: England |
Other Details:
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Languages: eng Pagination: 323-9 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Diseases, No. 2 Affiliated Hospital, College of Medicine, Zhejiang University, PR China. jian_an_wang@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Alcohol Drinking / adverse effects* Aorta / ultrasonography* Aortic Diseases / blood, etiology*, ultrasonography Atherosclerosis / blood, etiology*, ultrasonography Biological Markers / blood Cross-Sectional Studies Dilatation, Pathologic Female Humans Linear Models Lipids / blood* Lipoprotein(a) / blood* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Lipids; 0/Lipoprotein(a) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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