Document Detail


Relationship of growth and blood pressure in inbred rats.
MedLine Citation:
PMID:  8160862     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Blood pressure and body weight rise with age, and hypertension is hypothesized to result from an early disorder of growth. We used the statistical technique of spline fitting to examine patterns of growth and rising blood pressure in individual inbred rats of the Wistar-Kyoto, spontaneously hypertensive (SHR), and stroke-prone SHR strains. Our results indicate that growth is phasic and that a well-defined growth spurt peaks at approximately 50 days of age in each strain. In addition, the time of maximal weight gain corresponds to the onset of a blood pressure spurt. The timing of this blood pressure rise was similar in the three strains, but the maximal rate of blood pressure rise was significantly higher in the hypertensive strains. Our results suggest that growth and rising blood pressure are intimately linked. Blood pressure appears to rise in response to a growth spurt, suggesting that there are growth-related events that trigger the cardiovascular response.
Authors:
N J Schork; P Jokelainen; E J Grant; M A Schork; A B Weder
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  266     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-05-19     Completed Date:  1994-05-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R702-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Michigan, Ann Arbor 48109.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Blood Pressure*
Female
Male
Rats
Rats, Inbred SHR / genetics
Rats, Inbred WKY
Sex Characteristics
Grant Support
ID/Acronym/Agency:
HL-18575/HL/NHLBI NIH HHS; HL-R03-48957/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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