| Relationship of folate, vitamin B12 and methylation of insulin-like growth factor-II in maternal and cord blood. | |
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MedLine Citation:
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PMID: 21245875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/OBJECTIVE: One of the speculated mechanisms underlying fetal origin hypothesis of breast cancer is the possible influence of maternal environment on epigenetic regulation, such as changes in DNA methylation of the insulin-like growth factor-2 (IGF2) gene. The aim of the study is to investigate the relationship between folate, vitamin B(12) and methylation of the IGF2 gene in maternal and cord blood. SUBJECTS/METHODS: We conducted a cross-sectional study to measure methylation patterns of IGF2 in promoters 2 (P2) and promoters 3 (P3). RESULTS: The percentage of methylation in IGF2 P3 was higher in maternal blood than in cord blood (P<0.0001), whereas the methylation in P2 was higher in cord blood than in maternal blood (P=0.016). P3 methylation was correlated between maternal and cord blood (P<0.0001), but not P2 (P=0.06). The multivariate linear regression model showed that methylation patterns of both promoters in cord blood were not associated with serum folate levels in either cord or maternal blood, whereas the P3 methylation patterns were associated with serum levels of vitamin B(12) in mother's blood (mean change (MC)=-0.22, P=0.0014). Methylation patterns in P2 of maternal blood were associated with serum levels of vitamin B(12) in mother's blood (MC=-0.23, P=0.012), exposure to passive smoking (MC=0.46, P=0.034) and mother's weight gain during pregnancy (MC=0.23, P=0.019). CONCLUSIONS: The study suggests that environment influences methylation patterns in maternal blood, and then the maternal patterns influence the methylation status and levels of folate and vitamin B(12) in cord blood. |
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Authors:
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Y Ba; H Yu; F Liu; X Geng; C Zhu; Q Zhu; T Zheng; S Ma; G Wang; Z Li; Y Zhang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-01-19 |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 65 ISSN: 1476-5640 ISO Abbreviation: Eur J Clin Nutr Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-06 Completed Date: 2011-07-14 Revised Date: 2012-04-27 |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 480-5 Citation Subset: IM |
Copyright Information:
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© 2011 Macmillan Publishers Limited All rights reserved |
Affiliation:
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School of Public Health, Zhengzhou University, Zhengzhou, China. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Weight Cross-Sectional Studies DNA Methylation* Epigenomics Female Fetal Blood / chemistry* Folic Acid / blood* Humans Infant, Newborn Insulin-Like Growth Factor II / metabolism* Linear Models Male Pilot Projects Pregnancy Promoter Regions, Genetic Vitamin B 12 / blood* Vitamin B Complex |
| Grant Support | |
ID/Acronym/Agency:
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1D43TW007864-01/TW/FIC NIH HHS; 1D43TW008323-01/TW/FIC NIH HHS; R01 CA062006-06/CA/NCI NIH HHS; UL1 RR024139/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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12001-76-2/Vitamin B Complex; 59-30-3/Folic Acid; 67763-97-7/Insulin-Like Growth Factor II; 68-19-9/Vitamin B 12 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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