Document Detail


Relationship of first-trimester uterine artery Doppler to late stillbirth.
MedLine Citation:
PMID:  22508552     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study was to investigate if increased first-trimester uterine artery Doppler resistance indices (RI) are related to stillbirth.
METHOD: Uterine artery Doppler indices were assessed prospectively during a routine first-trimester ultrasound scan. Patients were categorised as having a high uterine artery mean Doppler RI if the index was above the 90th centile for gestation. Stillbirth outcomes were ascertained from a mandatory national register of pregnancy losses.
RESULTS: High RI uterine artery Doppler (>90th centile) was an independent risk factor for late (≥ 34 weeks) but not early stillbirth, with a hazard ratio of 2.61 (95% CI 1.13-6.03). The inclusion of uterine artery Doppler indices into Cox proportional hazard model negated the influence of conventional risk factors for stillbirth, such as parity, maternal age and body mass index (BMI), but not Afro-Caribbean ethnicity or smoking.
CONCLUSION: High first-trimester uterine artery Doppler RI is associated with late stillbirth after 34 weeks' gestation. This association supersedes those of conventional risk factors such as maternal age, parity and BMI, implying that these factors result in an increased risk of stillbirth by causing placental dysfunction.
Authors:
C Iacovella; M Franchi; M Egbor; A Bhide; B Thilaganathan
Publication Detail:
Type:  Journal Article     Date:  2012-04-17
Journal Detail:
Title:  Prenatal diagnosis     Volume:  32     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-24     Completed Date:  2012-09-18     Revised Date:  2013-01-11    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  557-61     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons, Ltd.
Affiliation:
Fetal Medicine Unit, Division of Clinical Developmental Sciences, St George's, University of London, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Female
Gestational Age*
Humans
Pregnancy
Pregnancy Complications, Cardiovascular / prevention & control,  ultrasonography*
Pregnancy Trimester, First
Risk Factors
Stillbirth / epidemiology*
Uterine Artery / physiopathology*,  ultrasonography*
Vascular Resistance*
Comments/Corrections
Comment In:
Prenat Diagn. 2012 Dec;32(12):1222; author reply 1223   [PMID:  23174762 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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