Document Detail

Relationship of fibrinogen with arterial stiffness and wave reflections.
MedLine Citation:
PMID:  17885555     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Increased levels of fibrinogen have been related to target organ damage and cardiovascular outcomes. Arterial elastic properties are important determinants of cardiovascular performance and predictors of the corresponding risk. This study investigated whether the fibrinogen level is associated with arterial stiffness and wave reflections. METHODS: We studied 229 consecutive, non-diabetic patients with uncomplicated, never-treated essential hypertension (mean age 51 years, 149 men) and an age-matched control group of 159 normotensive individuals (mean age 50 years, 83 men). Carotid-femoral and carotid-radial pulse wave velocity (PWVc-f and PWVc-r) were measured as indices of elastic-type, aortic stiffness and muscular type, medium-sized arterial stiffness, respectively. The heart rate-corrected augmentation index (AIx75) was estimated as a composite marker of wave reflections and arterial stiffness. Plasma fibrinogen was measured using immunonephelometry. RESULTS: The fibrinogen level and arterial function indices (PWVc-f, PWVc-r, AIx75) were significantly higher in hypertensive patients than controls. In the whole population, fibrinogen level correlated with PWVc-f and AIx75 in univariable analysis, but not with PWVc-r. In multivariable analysis, an independent association was established between fibrinogen level and PWVc-f after adjusting for age, sex, mean pressure, heart rate, height, body mass index, smoking status, and total cholesterol. In contrast, no significant relationship was observed between fibrinogen and AIx75 after adjusting for confounders. CONCLUSION: The plasma fibrinogen level is independently associated with aortic stiffening. This finding underlines the important role of fibrinogen as a marker of arterial damage, and implies a possible contribution of this compound to the pathophysiology of cardiovascular disease.
Charalambos Vlachopoulos; Panagiota Pietri; Konstantinos Aznaouridis; Gregory Vyssoulis; Carmen Vasiliadou; Athanasios Bratsas; Dimitris Tousoulis; Panagiotis Xaplanteris; Elli Stefanadi; Christodoulos Stefanadis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  25     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-21     Completed Date:  2008-01-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  2110-6     Citation Subset:  IM    
Hypertension Unit, 1st Department of Cardiology, Athens Medical School, Hippokration Hospital, Athens, Greece.
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MeSH Terms
Arteries / physiopathology*
Biological Markers / blood
Cardiovascular Diseases / etiology,  physiopathology
Case-Control Studies
Fibrinogen / physiology*
Hypertension / blood,  complications,  physiopathology*
Middle Aged
Multivariate Analysis
Risk Factors
Reg. No./Substance:
0/Biological Markers; 9001-32-5/Fibrinogen

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