Document Detail

Relationship of endogenous levels of sex hormones to cognition and depression in frail, elderly women.
MedLine Citation:
PMID:  11994219     Owner:  NLM     Status:  MEDLINE    
Neuropsychological evaluations and sex hormone assays for 188 elderly, female nursing home residents (mean age: 87.8 years; standard deviation: 7.0 years) revealed inverse relationships for dehydroepiandrosterone (DHEA) blood levels and cognition scores based on the Mini-Mental State Exam and the Test for Severe Impairment, as well as for scores of the Immediate Recall, Copy, and Recognition tests of the Visual Reproduction subtest of the Wechsler Memory Scale-Revised (WMS-R; VR). A positive correlation between estrone and depression approached significance, as did the inverse relationships between the Recognition scores of the WMS-R; VR with androstenedione. These results and findings of others suggest that sex hormone actions in elderly women may differ from those in younger populations. A possible stress-related mechanism is also posited.
Brenda Breuer; Charles Martucci; Sylvan Wallenstein; Antonios Likourezos; Leslie S Libow; Ann Peterson; Barnett Zumoff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry     Volume:  10     ISSN:  1064-7481     ISO Abbreviation:  Am J Geriatr Psychiatry     Publication Date:    2002 May-Jun
Date Detail:
Created Date:  2002-05-07     Completed Date:  2002-10-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9309609     Medline TA:  Am J Geriatr Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  311-20     Citation Subset:  IM    
The Jewish Home and Hospital of New York, NY, USA.
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MeSH Terms
Aged, 80 and over
Cognition Disorders / blood*,  psychology*
Depressive Disorder / blood*,  psychology*
Frail Elderly / psychology
Gonadal Steroid Hormones / blood*
New York
Nursing Homes
Reg. No./Substance:
0/Gonadal Steroid Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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