| Relationship of dysregulation of glucose metabolism with white-coat hypertension: the Ohasama study. | |
| | |
MedLine Citation:
|
PMID: 20631718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Characteristics of glucose metabolism in subjects with white-coat hypertension (WCHT) have not been fully investigated. The purpose of this study was to determine the relationship between glucose metabolism and WCHT on the basis of blood pressure (BP) at home (HBP) in the general population. Participants were from Ohasama, a rural Japanese community, and included 466 residents (mean age, 61.0 years) who had no history of diabetes mellitus. HBP and oral glucose tolerance test values were measured. Participants were classified into four groups on the basis of their HBP and casual-screening BP (CBP) values: normotension (NT) (HBP<135/85 mm Hg, CBP<140/90 mm Hg); WCHT (HBP<135/85 mm Hg, CBP>/=140/90 mm Hg); masked hypertension (HBP>/=135/85 mm Hg, CBP<140/90 mm Hg); or sustained hypertension (SHT) (HBP>/=135/85 mm Hg, CBP>/=140/90 mm Hg). The relationships between glucose metabolism and BP among the four groups were examined using multivariate analysis adjusted for possible confounding factors. Factors in relation to glucose metabolism, such as fasting glucose level, 2-h postchallenge glucose level and homeostasis model assessment-insulin resistance index, were significantly higher in subjects with WCHT and SHT than in those with NT (all P<0.03). When men and women were analyzed separately, these relationships were more pronounced in women. Our results suggest that dysregulation of glucose metabolism in WCHT might contribute to the increase in the long-term cardiovascular risk among the general population. |
| | |
Authors:
|
Miki Hosaka; Akira Mimura; Kei Asayama; Takayoshi Ohkubo; Katsuhisa Hayashi; Masahiro Kikuya; Michihiro Sato; Takanao Hashimoto; Atsuhiro Kanno; Azusa Hara; Taku Obara; Hirohito Metoki; Ryusuke Inoue; Haruhisa Hoshi; Hiroshi Satoh; Yoshitomo Oka; Yutaka Imai |
Related Documents
:
|
18206598 - Effectiveness of eprosartan in diabetic hypertensive patients. 10842668 - Molecular pathology in the obese spontaneous hypertensive koletsky rat: a model of synd... 18815738 - Tea polyphenols benefit vascular function. 14688488 - Hypertension in the metabolic syndrome and diabetes: pathogenesis, clinical studies, an... 18431508 - Adiponectin regulates albuminuria and podocyte function in mice. 11141648 - Vital capillary microscopic findings in the nailfold of patients with diabetes mellitus. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-15 |
Journal Detail:
|
Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 33 ISSN: 1348-4214 ISO Abbreviation: Hypertens. Res. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-06 Completed Date: 2010-12-31 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: England |
Other Details:
|
Languages: eng Pagination: 937-43 Citation Subset: IM |
Affiliation:
|
Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Blood Pressure / physiology Blood Pressure Monitoring, Ambulatory Cardiovascular Diseases / epidemiology Female Glucose / metabolism* Glucose Tolerance Test Humans Hypertension / diagnosis, epidemiology* Insulin Resistance / physiology Japan / epidemiology Longitudinal Studies Male Middle Aged Sex Factors |
| Chemical | |
Reg. No./Substance:
|
50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Should we send our kids to the gym?
Next Document: A novel GATA6 mutation in patients with tetralogy of Fallot or atrial septal defect.