| Relationship of dietary cholesterol to blood pressure: the INTERMAP study. | |
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MedLine Citation:
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PMID: 21045731 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: A direct relationship of dietary cholesterol to blood pressure of men has been reported in a few observational studies from the USA. It is not clear whether this association prevails consistently, for example, in populations with varied dietary habits, across ethnic groups, and sexes. Cross-sectional data from the International Study of Macro/Micro-nutrients and Blood Pressure (INTERMAP) were used to assess relations of dietary cholesterol intake to blood pressure in men and women from four countries. METHODS: Data include 83 nutrients from four multipass 24-h dietary recalls and two-timed 24-h urine collections; eight blood pressure readings, and questionnaire data, for 4680 participants ages 40-59 years from 17 population samples in Japan, People's Republic of China, UK, and USA. RESULTS: With sequential models to control for multiple possible confounders (dietary, other), linear regression analyses showed that dietary cholesterol was directly related to SBP for all participants and for nonhypertensive individuals, but not to DBP. With adjustment for 12 variables, estimated SBP differences with 2SD for higher cholesterol intake (131.0 mg/1000 kcal) were 0.9 mmHg (P < 0.05) for all participants and 1.1 mmHg (P < 0.01) for nonhypertensive individuals, findings attenuated with addition of height and weight to the model. CONCLUSION: INTERMAP found a low-order, positive relationship of dietary cholesterol intake to SBP with control for multiple possible confounders. Reduction of dietary cholesterol intake may contribute to prevention and control of adverse blood pressure levels in general populations. |
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Authors:
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Masaru Sakurai; Jeremiah Stamler; Katsuyuki Miura; Ian J Brown; Hideaki Nakagawa; Paul Elliott; Hirotsugu Ueshima; Queenie Chan; Ioanna Tzoulaki; Alan R Dyer; Akira Okayama; Liancheng Zhao; |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 29 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2010-12-30 Completed Date: 2011-05-04 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 222-8 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Public Health, Kanazawa Medical University, Ishikawa, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / physiology* China Cholesterol, Dietary / administration & dosage*, adverse effects* Cross-Sectional Studies Diet Female Food Great Britain Humans Hypertension / etiology*, physiopathology, prevention & control Japan Male Middle Aged Regression Analysis Risk Factors United States |
| Grant Support | |
ID/Acronym/Agency:
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2-RO1-HL50490/HL/NHLBI NIH HHS; R01 HL050490-05/HL/NHLBI NIH HHS; R01 HL050490-06/HL/NHLBI NIH HHS; R01 HL050490-07/HL/NHLBI NIH HHS; R01 HL050490-08/HL/NHLBI NIH HHS; R01 HL050490-08S1/HL/NHLBI NIH HHS; R01 HL050490-09/HL/NHLBI NIH HHS; R01 HL050490-10/HL/NHLBI NIH HHS; R01 HL050490-11/HL/NHLBI NIH HHS; R01 HL050490-12/HL/NHLBI NIH HHS; R01 HL050490-13/HL/NHLBI NIH HHS; R01 HL050490-14/HL/NHLBI NIH HHS; R01 HL050490-15/HL/NHLBI NIH HHS; R01 HL050490-16/HL/NHLBI NIH HHS; R01 HL050490-17/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, Dietary |
| Comments/Corrections | |
Comment In:
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J Hypertens. 2011 Feb;29(2):194-7
[PMID:
21191277
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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